Neutrophils in aging and aging-related pathologies

Kristof Van Avondt; Jan Kolja Strecker; Claudia Tulotta; Jens Minnerup; Christian Schulz; Oliver Soehnlein

doi:10.1111/imr.13153

Neutrophils in aging and aging-related pathologies

Kristof Van Avondt^*, Jan Kolja Strecker, Claudia Tulotta, Jens Minnerup, Christian Schulz, Oliver Soehnlein^*

^*Corresponding author for this work

125 Citations (Scopus)

Abstract

Over the past millennia, life expectancy has drastically increased. While a mere 25 years during Bronze and Iron ages, life expectancy in many European countries and in Japan is currently above 80 years. Such an increase in life expectancy is a result of improved diet, life style, and medical care. Yet, increased life span and aging also represent the most important non-modifiable risk factors for several pathologies including cardiovascular disease, neurodegenerative diseases, and cancer. In recent years, neutrophils have been implicated in all of these pathologies. Hence, this review provides an overview of how aging impacts neutrophil production and function and conversely how neutrophils drive aging-associated pathologies. Finally, we provide a perspective on how processes of neutrophil-driven pathologies in the context of aging can be targeted therapeutically.

Original language	English
Journal	Immunological Reviews
Volume	314
Issue number	1
Pages (from-to)	357-375
Number of pages	19
ISSN	0105-2896
DOIs	https://doi.org/10.1111/imr.13153
Publication status	Published - 03.2023

Funding

Funders	Funder number
International Myeloma Foundation
Alexander von Humboldt Foundation
Deutsches Zentrum für Herz-Kreislaufforschung
Deutsche Forschungsgemeinschaft	CRC TRR332 TP B2, MI 1547/4–1, MI 1547/3‐1, FOR 2879/1
Fondation Leducq
Bundesministerium für Bildung und Forschung	CRC914 TP B8, CRC TRR332 TP A2 & Z1, CRC1123 TP A6, CRC1123 TP A7, CRC914 TP A10, SCHU 2297/1‐1, CRC1009 TP A13, CRC TRR332 TP A6, OR465/1‐1, 81Z060020
Else Kröner-Fresenius-Stiftung
Novo Nordisk Foundation
Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Würzburg

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 6 Clean Water and Sanitation
SDG 10 Reduced Inequalities

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

DFG Research Classification Scheme

2.21-03 Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology
2.23-07 Clinical Neurology, Neurosurgery and Neuroradiology
2.21-05 Immunology

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10.1111/imr.13153

Cite this

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title = "Neutrophils in aging and aging-related pathologies",

abstract = "Over the past millennia, life expectancy has drastically increased. While a mere 25 years during Bronze and Iron ages, life expectancy in many European countries and in Japan is currently above 80 years. Such an increase in life expectancy is a result of improved diet, life style, and medical care. Yet, increased life span and aging also represent the most important non-modifiable risk factors for several pathologies including cardiovascular disease, neurodegenerative diseases, and cancer. In recent years, neutrophils have been implicated in all of these pathologies. Hence, this review provides an overview of how aging impacts neutrophil production and function and conversely how neutrophils drive aging-associated pathologies. Finally, we provide a perspective on how processes of neutrophil-driven pathologies in the context of aging can be targeted therapeutically.",

author = "\{Van Avondt\}, Kristof and Strecker, \{Jan Kolja\} and Claudia Tulotta and Jens Minnerup and Christian Schulz and Oliver Soehnlein",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors. Immunological Reviews published by John Wiley \& Sons Ltd.",

year = "2023",

month = mar,

doi = "10.1111/imr.13153",

language = "English",

volume = "314",

pages = "357--375",

journal = "Immunological Reviews",

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TY - JOUR

T1 - Neutrophils in aging and aging-related pathologies

AU - Van Avondt, Kristof

AU - Strecker, Jan Kolja

AU - Tulotta, Claudia

AU - Minnerup, Jens

AU - Schulz, Christian

AU - Soehnlein, Oliver

PY - 2023/3

Y1 - 2023/3

N2 - Over the past millennia, life expectancy has drastically increased. While a mere 25 years during Bronze and Iron ages, life expectancy in many European countries and in Japan is currently above 80 years. Such an increase in life expectancy is a result of improved diet, life style, and medical care. Yet, increased life span and aging also represent the most important non-modifiable risk factors for several pathologies including cardiovascular disease, neurodegenerative diseases, and cancer. In recent years, neutrophils have been implicated in all of these pathologies. Hence, this review provides an overview of how aging impacts neutrophil production and function and conversely how neutrophils drive aging-associated pathologies. Finally, we provide a perspective on how processes of neutrophil-driven pathologies in the context of aging can be targeted therapeutically.

AB - Over the past millennia, life expectancy has drastically increased. While a mere 25 years during Bronze and Iron ages, life expectancy in many European countries and in Japan is currently above 80 years. Such an increase in life expectancy is a result of improved diet, life style, and medical care. Yet, increased life span and aging also represent the most important non-modifiable risk factors for several pathologies including cardiovascular disease, neurodegenerative diseases, and cancer. In recent years, neutrophils have been implicated in all of these pathologies. Hence, this review provides an overview of how aging impacts neutrophil production and function and conversely how neutrophils drive aging-associated pathologies. Finally, we provide a perspective on how processes of neutrophil-driven pathologies in the context of aging can be targeted therapeutically.

UR - https://www.scopus.com/pages/publications/85141374900

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DO - 10.1111/imr.13153

M3 - Scientific review articles

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AN - SCOPUS:85141374900

SN - 0105-2896

VL - 314

SP - 357

EP - 375

JO - Immunological Reviews

JF - Immunological Reviews

IS - 1

ER -

Neutrophils in aging and aging-related pathologies

Abstract

Funding

UN SDGs

Research Areas and Centers

DFG Research Classification Scheme

Access to Document

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