Neutrophils as potential safe niche for Leishmania and Anaplasma

Ger Van Zandbergen*, Elena Bank, Martina Behnen, Matthias Klinger, Tamas Laskay

*Corresponding author for this work


Neutrophils are the most crucial cells for early defence against infections. When properly activated they can kill extracellular pathogens but also also obligate intracellular pathogens such as Leishmania and Anaplasma. However, once the phagocytotic killing has been evaded, neutrophils can serve as host cells for obligate intracellular pathogens. Parasitized neutrophils were shown to function as a 'Trojan horse', to silently transfer Leishmania to macrophages as well as Anaplasma to other neutrophils. Here, we discuss the Trojan horse function of neutrophils for Leishmania and Anaplasma.

Original languageEnglish
Title of host publicationNeutrophils in Infectious Diseases
Number of pages10
PublisherBentham Science Publishers Ltd.
Publication date01.12.2011
ISBN (Print)9781608053827
Publication statusPublished - 01.12.2011

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


Dive into the research topics of 'Neutrophils as potential safe niche for Leishmania and Anaplasma'. Together they form a unique fingerprint.

Cite this