Neutrophils as potential safe niche for Leishmania and Anaplasma

Ger Van Zandbergen; Elena Bank; Martina Behnen; Matthias Klinger; Tamas Laskay

doi:10.2174/978160805023911101010067

Neutrophils as potential safe niche for Leishmania and Anaplasma

Ger Van Zandbergen^*, Elena Bank, Martina Behnen, Matthias Klinger, Tamas Laskay

^*Corresponding author for this work

Institute of Chemistry and Metabolomics

University of Ulm

Abstract

Neutrophils are the most crucial cells for early defence against infections. When properly activated they can kill extracellular pathogens but also also obligate intracellular pathogens such as Leishmania and Anaplasma. However, once the phagocytotic killing has been evaded, neutrophils can serve as host cells for obligate intracellular pathogens. Parasitized neutrophils were shown to function as a 'Trojan horse', to silently transfer Leishmania to macrophages as well as Anaplasma to other neutrophils. Here, we discuss the Trojan horse function of neutrophils for Leishmania and Anaplasma.

Original language	English
Title of host publication	Neutrophils in Infectious Diseases
Number of pages	10
Publisher	Bentham Science Publishers Ltd.
Publication date	01.12.2011
Pages	67-76
ISBN (Print)	9781608053827
DOIs	https://doi.org/10.2174/978160805023911101010067
Publication status	Published - 01.12.2011

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2174/978160805023911101010067

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AU - Behnen, Martina

AU - Klinger, Matthias

AU - Laskay, Tamas

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Neutrophils as potential safe niche for Leishmania and Anaplasma

Abstract

Research Areas and Centers

UN SDGs

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