Neuropsychological and neurophysiological findings in individuals suspected to be at risk for schizophrenia: Preliminary results from the Basel early detection of psychosis study - Früherkennung von Psychosen (FEPSY)

Ute Gschwandtner*, J. Aston, S. Borgwardt, M. Drewe, C. Feinendegen, D. Lacher, A. Lanzarone, R. D. Stieglitz, A. Riecher-Rössler

*Corresponding author for this work
52 Citations (Scopus)

Abstract

Objective: Our study aims to establish a scientific basis for the very early detection of patients at risk for schizophrenia during the nonspecific prodromal phase of the disorder and to predict its outbreak. Method: A multidomain approach is used. After screening, approved psychopathological, neurophysiological, neuropsychotogical and neuroradiological investigations are used to assess a sample of individuals suspected to be at risk for schizophrenia. Results: Neuropsychological and fine motor functioning tests as well as eye movement measurements showed statistically significant differences (P < 0.01) between individuals suspected to be at risk for schizophrenia and healthy controls. Conclusion: Individuals suspected to be at risk for schizophrenia show specific impairments in various investigations including neuropsychological and fine motor functioning tests as well as eye movement measurements. A set of methods sensitive to even subtle changes in normal functioning may prove useful in predicting the subsequent outbreak of schizophrenia.

Original languageEnglish
JournalActa Psychiatrica Scandinavica
Volume108
Issue number2
Pages (from-to)152-155
Number of pages4
ISSN0001-690X
DOIs
Publication statusPublished - 01.08.2003

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