TY - JOUR
T1 - Neuroprotective effect of Fn14 deficiency is associated with induction of the granulocyte-colony stimulating factor (G-CSF) pathway in experimental stroke and enhanced by a pathogenic human antiphospholipid antibody
AU - Frauenknecht, Katrin
AU - Bargiotas, Panagiotis
AU - Bauer, Henrike
AU - von Landenberg, Philipp
AU - Schwaninger, Markus
AU - Sommer, Clemens
PY - 2010/10/1
Y1 - 2010/10/1
N2 - Using a transgenic mouse model of ischemic stroke we checked for a possible interaction of antiphospholipid antibodies (aPL) which often cause thromboses as well as central nervous system (CNS) involvement under non-thrombotic conditions and the TWEAK/Fn14 pathway known to be adversely involved in inflammatory and ischemic brain disease. After 7. days, infarct volumes were reduced in Fn14 deficient mice and were further decreased by aPL treatment. This was associated with strongest increase of the endogenous neuroprotective G-CSF/G-CSF receptor system. This unexpected beneficial action of aPL is an example for a non-thrombogenic action and the double-edged nature of aPL.
AB - Using a transgenic mouse model of ischemic stroke we checked for a possible interaction of antiphospholipid antibodies (aPL) which often cause thromboses as well as central nervous system (CNS) involvement under non-thrombotic conditions and the TWEAK/Fn14 pathway known to be adversely involved in inflammatory and ischemic brain disease. After 7. days, infarct volumes were reduced in Fn14 deficient mice and were further decreased by aPL treatment. This was associated with strongest increase of the endogenous neuroprotective G-CSF/G-CSF receptor system. This unexpected beneficial action of aPL is an example for a non-thrombogenic action and the double-edged nature of aPL.
UR - http://www.scopus.com/inward/record.url?scp=77956651450&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2010.05.043
DO - 10.1016/j.jneuroim.2010.05.043
M3 - Journal articles
C2 - 20557950
AN - SCOPUS:77956651450
SN - 0165-5728
VL - 227
SP - 1
EP - 9
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -