Neuronal NF-κB influences thermoregulation and survival in a sepsis model

Eric Jüttler, Ioana Inta, Verena Eigler, Oliver Herrmann, Ira Maegele, Christiane Maser-Gluth, Markus Schwaninger*

*Corresponding author for this work
12 Citations (Scopus)


Gene regulation in sepsis is known to be controlled by the transcription factor NF-κB. However, the function of neuronal NF-κB in sepsis is not well defined. In a mouse model of sepsis induced by i.p. injection of lipopolysaccharides (LPS), we found an activation of NF-κB in the brain as shown by the induction of a transgenic NF-κB reporter. Inhibition of neuronal NF-κB by cell-specific expression of the NF-κB super-repressor IκBα-SR improved LPS-induced hypothermia and survival but had no effect on body weight or on the humoral response to LPS. In contrast, glial inhibition of NF-κB did not influence body temperature and survival. By immunohistochemistry, we detected the active NF-κB subunit RelA in neuronal nuclei of the organum vasculosum of the lamina terminalis. Our data reveal an important role of neuronal NF-κB in thermoregulation and survival. The upcoming group of NF-κB inhibitors may have a place in the treatment of the acute-phase response.

Original languageEnglish
JournalJournal of Neuroimmunology
Issue number1-2
Pages (from-to)41-49
Number of pages9
Publication statusPublished - 01.09.2007

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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