Neuromotor development and mental health at 5.5 years of age of singletons born at term after intracytoplasmatic sperm injection ICSI: results of a prospective controlled single-blinded study in Germany

Annika Ludwig; Alexander Katalinic; Ute Thyen; Alastair G. Sutcliffe; Klaus Diedrich; Michael Ludwig

doi:10.1016/j.fertnstert.2007.11.030

Neuromotor development and mental health at 5.5 years of age of singletons born at term after intracytoplasmatic sperm injection ICSI: results of a prospective controlled single-blinded study in Germany

Annika Ludwig^*, Alexander Katalinic, Ute Thyen, Alastair G. Sutcliffe, Klaus Diedrich, Michael Ludwig

^*Corresponding author for this work

44 Citations (Scopus)

Abstract

Objective: To assess the neurodevelopmental health of children born after intracytoplasmatic sperm injection (ICSI). Design: Prospective controlled blinded study. Setting: Tertiary care center. Patient(s): A total of 276 term-born singletons conceived by ICSI and 273 matched spontaneously conceived (SC) singletons at the age of 5.5 years. Main Outcome Measure(s): Neuromotor development assessed by a detailed neurologic examination, including the standardized motor test MOT 4-6, and emotional/behavioral development and intelligence assessed with the Kaufman-Assessment Battery for Children. Result(s): There were no significant differences between ICSI children and control children regarding the neurologic examination, motor skills, emotional/behavioral development, and intelligence. Conclusion(s): The ICSI children born at term develop normally, similar to SC children.

Original language	English
Journal	Fertility and Sterility
Volume	91
Issue number	1
Pages (from-to)	125-132
Number of pages	8
ISSN	0015-0282
DOIs	https://doi.org/10.1016/j.fertnstert.2007.11.030
Publication status	Published - 01.01.2009

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10.1016/j.fertnstert.2007.11.030

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Ludwig, A., Katalinic, A., Thyen, U., Sutcliffe, A. G., Diedrich, K., & Ludwig, M. (2009). Neuromotor development and mental health at 5.5 years of age of singletons born at term after intracytoplasmatic sperm injection ICSI: results of a prospective controlled single-blinded study in Germany. Fertility and Sterility, 91(1), 125-132. https://doi.org/10.1016/j.fertnstert.2007.11.030

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title = "Neuromotor development and mental health at 5.5 years of age of singletons born at term after intracytoplasmatic sperm injection ICSI: results of a prospective controlled single-blinded study in Germany",

abstract = "Objective: To assess the neurodevelopmental health of children born after intracytoplasmatic sperm injection (ICSI). Design: Prospective controlled blinded study. Setting: Tertiary care center. Patient(s): A total of 276 term-born singletons conceived by ICSI and 273 matched spontaneously conceived (SC) singletons at the age of 5.5 years. Main Outcome Measure(s): Neuromotor development assessed by a detailed neurologic examination, including the standardized motor test MOT 4-6, and emotional/behavioral development and intelligence assessed with the Kaufman-Assessment Battery for Children. Result(s): There were no significant differences between ICSI children and control children regarding the neurologic examination, motor skills, emotional/behavioral development, and intelligence. Conclusion(s): The ICSI children born at term develop normally, similar to SC children.",

author = "Annika Ludwig and Alexander Katalinic and Ute Thyen and Sutcliffe, \{Alastair G.\} and Klaus Diedrich and Michael Ludwig",

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doi = "10.1016/j.fertnstert.2007.11.030",

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Ludwig, A, Katalinic, A, Thyen, U, Sutcliffe, AG, Diedrich, K & Ludwig, M 2009, 'Neuromotor development and mental health at 5.5 years of age of singletons born at term after intracytoplasmatic sperm injection ICSI: results of a prospective controlled single-blinded study in Germany', Fertility and Sterility, vol. 91, no. 1, pp. 125-132. https://doi.org/10.1016/j.fertnstert.2007.11.030

Neuromotor development and mental health at 5.5 years of age of singletons born at term after intracytoplasmatic sperm injection ICSI: results of a prospective controlled single-blinded study in Germany. / Ludwig, Annika; Katalinic, Alexander; Thyen, Ute et al.
In: Fertility and Sterility, Vol. 91, No. 1, 01.01.2009, p. 125-132.

Research output: Journal Articles › Journal articles › Research › peer-review

TY - JOUR

T1 - Neuromotor development and mental health at 5.5 years of age of singletons born at term after intracytoplasmatic sperm injection ICSI

T2 - results of a prospective controlled single-blinded study in Germany

AU - Ludwig, Annika

AU - Katalinic, Alexander

AU - Thyen, Ute

AU - Sutcliffe, Alastair G.

AU - Diedrich, Klaus

AU - Ludwig, Michael

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Objective: To assess the neurodevelopmental health of children born after intracytoplasmatic sperm injection (ICSI). Design: Prospective controlled blinded study. Setting: Tertiary care center. Patient(s): A total of 276 term-born singletons conceived by ICSI and 273 matched spontaneously conceived (SC) singletons at the age of 5.5 years. Main Outcome Measure(s): Neuromotor development assessed by a detailed neurologic examination, including the standardized motor test MOT 4-6, and emotional/behavioral development and intelligence assessed with the Kaufman-Assessment Battery for Children. Result(s): There were no significant differences between ICSI children and control children regarding the neurologic examination, motor skills, emotional/behavioral development, and intelligence. Conclusion(s): The ICSI children born at term develop normally, similar to SC children.

AB - Objective: To assess the neurodevelopmental health of children born after intracytoplasmatic sperm injection (ICSI). Design: Prospective controlled blinded study. Setting: Tertiary care center. Patient(s): A total of 276 term-born singletons conceived by ICSI and 273 matched spontaneously conceived (SC) singletons at the age of 5.5 years. Main Outcome Measure(s): Neuromotor development assessed by a detailed neurologic examination, including the standardized motor test MOT 4-6, and emotional/behavioral development and intelligence assessed with the Kaufman-Assessment Battery for Children. Result(s): There were no significant differences between ICSI children and control children regarding the neurologic examination, motor skills, emotional/behavioral development, and intelligence. Conclusion(s): The ICSI children born at term develop normally, similar to SC children.

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DO - 10.1016/j.fertnstert.2007.11.030

M3 - Journal articles

C2 - 18281037

AN - SCOPUS:57849123106

SN - 0015-0282

VL - 91

SP - 125

EP - 132

JO - Fertility and Sterility

JF - Fertility and Sterility

IS - 1

ER -

Neuromotor development and mental health at 5.5 years of age of singletons born at term after intracytoplasmatic sperm injection ICSI: results of a prospective controlled single-blinded study in Germany

Abstract

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ICSI-2: Prospective, controlled study of children aged 5 to 6 years born after intracytoplasmic sperm injection (ICSI)

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Neuromotor development and mental health at 5.5 years of age of singletons born at term after intracytoplasmatic sperm injection ICSI: results of a prospective controlled single-blinded study in Germany

Abstract

UN SDGs

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ICSI-2: Prospective, controlled study of children aged 5 to 6 years born after intracytoplasmic sperm injection (ICSI)

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