Neuromotor development and mental health at 5.5 years of age of singletons born at term after intracytoplasmatic sperm injection ICSI: results of a prospective controlled single-blinded study in Germany

Annika Ludwig*, Alexander Katalinic, Ute Thyen, Alastair G. Sutcliffe, Klaus Diedrich, Michael Ludwig

*Corresponding author for this work
28 Citations (Scopus)

Abstract

Objective: To assess the neurodevelopmental health of children born after intracytoplasmatic sperm injection (ICSI). Design: Prospective controlled blinded study. Setting: Tertiary care center. Patient(s): A total of 276 term-born singletons conceived by ICSI and 273 matched spontaneously conceived (SC) singletons at the age of 5.5 years. Main Outcome Measure(s): Neuromotor development assessed by a detailed neurologic examination, including the standardized motor test MOT 4-6, and emotional/behavioral development and intelligence assessed with the Kaufman-Assessment Battery for Children. Result(s): There were no significant differences between ICSI children and control children regarding the neurologic examination, motor skills, emotional/behavioral development, and intelligence. Conclusion(s): The ICSI children born at term develop normally, similar to SC children.

Original languageEnglish
JournalFertility and Sterility
Volume91
Issue number1
Pages (from-to)125-132
Number of pages8
ISSN0015-0282
DOIs
Publication statusPublished - 01.01.2009

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