Neuroma formation in a rat median nerve model: Influence of distal stump and muscular coating

Nektarios Sinis*, Max Haerle, Stephan Thomas Becker, Caterina Schulte-Eversum, Reinhard Vonthein, Harald Rösner, Hans Eberhard Schaller

*Corresponding author for this work
24 Citations (Scopus)


BACKGROUND: The purpose of this study was to investigate neuroma formation in a rat median nerve model. METHODS: In three groups, the median nerve was exposed and a gap was created. In the first group, a short gap of 1 cm (n = 12) was created; in the second, a long gap of 2 cm (n = 12) was created in the nerve. Another group was used to analyze the development of neuroma formation when the proximal stump was buried in adjacent muscle with an additional gap of 2 cm (n = 12). The use of different lengths should allow one to gain information about dilution effects of distal stump factors that may contribute to neuroma formation. Nine months later, specimens were gathered and histologically analyzed. The cross-sectional areas of neuromas were measured and the neural/connective tissue ratios were estimated. RESULTS: The cross-sectional areas demonstrated that neuroma formation was significantly higher in the short-gap group than in the long-gap group, and smallest in the muscle-covered group. The percentage of neural tissue was highest in the muscle-covered and long-gap groups and lowest in the short-gap group. CONCLUSIONS: These results demonstrate an association between neuroma formation and distal stump distance. This observation may be explained by the factors originating from the distal stump that were blocked when the proximal nerve stump was completely buried in the muscle. For clinical application, the authors recommend not only burying the proximal stump in a muscle but also surgically augmenting the gap between the proximal and distal stumps.

Original languageEnglish
JournalPlastic and Reconstructive Surgery
Issue number3
Pages (from-to)960-966
Number of pages7
Publication statusPublished - 03.2007


Dive into the research topics of 'Neuroma formation in a rat median nerve model: Influence of distal stump and muscular coating'. Together they form a unique fingerprint.

Cite this