In this review we discuss pathophysiological concepts of obsessive-compulsive disorder (OCD) based on current neurobiological findings. Neurobiological concepts of OCD are based on findings from clinical and experimental pharmacology, neuroimaging and neurophysiology. They have been developed with reference to neurological disorders of the basal ganglion, in particular the Tourette syndrome. Current associations of genetic polymorphisms with clinical phenotypes support both, heredity and genetic heterogeneity of the disorder. Indirectly, these observations will have an impact on diagnostic concepts and even treatment of OCD.
|Translated title of the contribution||Neurobiology of obsessive-compulsive disorder - Part 1: Pathophysiological and genetic concepts|
|Number of pages||6|
|Publication status||Published - 2009|
Research Areas and Centers
- Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)