Neural Basis of Δ-9-Tetrahydrocannabinol and Cannabidiol: Effects During Response Inhibition

Stefan J. Borgwardt; Paul Allen; Sagnik Bhattacharyya; Paolo Fusar-Poli; Jose A. Crippa; Marc L. Seal; Valter Fraccaro; Zerrin Atakan; Rocio Martin-Santos; Colin O'Carroll; Katya Rubia; Philip K. McGuire

doi:10.1016/j.biopsych.2008.05.011

Neural Basis of Δ-9-Tetrahydrocannabinol and Cannabidiol: Effects During Response Inhibition

Stefan J. Borgwardt^*, Paul Allen, Sagnik Bhattacharyya, Paolo Fusar-Poli, Jose A. Crippa, Marc L. Seal, Valter Fraccaro, Zerrin Atakan, Rocio Martin-Santos, Colin O'Carroll, Katya Rubia, Philip K. McGuire

^*Corresponding author for this work

Clinic of Psychiatry and Psychotherapy

174 Citations (Scopus)

Abstract

Background: This study examined the effect of Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on brain activation during a motor inhibition task. Methods: Functional magnetic resonance imaging and behavioural measures were recorded while 15 healthy volunteers performed a Go/No-Go task following administration of either THC or CBD or placebo in a double-blind, pseudo-randomized, placebo-controlled repeated measures within-subject design. Results: Relative to placebo, THC attenuated activation in the right inferior frontal and the anterior cingulate gyrus. In contrast, CBD deactivated the left temporal cortex and insula. These effects were not related to changes in anxiety, intoxication, sedation, and psychotic symptoms. Conclusions: These data suggest that THC attenuates the engagement of brain regions that mediate response inhibition. CBD modulated function in regions not usually implicated in response inhibition.

Original language	English
Journal	Biological Psychiatry
Volume	64
Issue number	11
Pages (from-to)	966-973
Number of pages	8
ISSN	0006-3223
DOIs	https://doi.org/10.1016/j.biopsych.2008.05.011
Publication status	Published - 01.12.2008

Funding

This study was supported by grants from the Psychiatry Research Trust, United Kingdom. SB is supported by an MRC Clinical Research Training Fellowship. PFP is supported by the Guy's & St. Thomas' Charitable Foundation, New Services and Innovations in Health Care. All authors have agreed to the submission of this article in this form, and we do not have any conflict interests that might be interpreted as influencing its content.

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title = "Neural Basis of Δ-9-Tetrahydrocannabinol and Cannabidiol: Effects During Response Inhibition",

abstract = "Background: This study examined the effect of Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on brain activation during a motor inhibition task. Methods: Functional magnetic resonance imaging and behavioural measures were recorded while 15 healthy volunteers performed a Go/No-Go task following administration of either THC or CBD or placebo in a double-blind, pseudo-randomized, placebo-controlled repeated measures within-subject design. Results: Relative to placebo, THC attenuated activation in the right inferior frontal and the anterior cingulate gyrus. In contrast, CBD deactivated the left temporal cortex and insula. These effects were not related to changes in anxiety, intoxication, sedation, and psychotic symptoms. Conclusions: These data suggest that THC attenuates the engagement of brain regions that mediate response inhibition. CBD modulated function in regions not usually implicated in response inhibition.",

author = "Borgwardt, \{Stefan J.\} and Paul Allen and Sagnik Bhattacharyya and Paolo Fusar-Poli and Crippa, \{Jose A.\} and Seal, \{Marc L.\} and Valter Fraccaro and Zerrin Atakan and Rocio Martin-Santos and Colin O'Carroll and Katya Rubia and McGuire, \{Philip K.\}",

note = "Funding Information: This study was supported by grants from the Psychiatry Research Trust, United Kingdom. SB is supported by an MRC Clinical Research Training Fellowship. PFP is supported by the Guy's \& St. Thomas' Charitable Foundation, New Services and Innovations in Health Care. All authors have agreed to the submission of this article in this form, and we do not have any conflict interests that might be interpreted as influencing its content. ",

year = "2008",

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doi = "10.1016/j.biopsych.2008.05.011",

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T1 - Neural Basis of Δ-9-Tetrahydrocannabinol and Cannabidiol

T2 - Effects During Response Inhibition

AU - Borgwardt, Stefan J.

AU - Allen, Paul

AU - Bhattacharyya, Sagnik

AU - Fusar-Poli, Paolo

AU - Crippa, Jose A.

AU - Seal, Marc L.

AU - Fraccaro, Valter

AU - Atakan, Zerrin

AU - Martin-Santos, Rocio

AU - O'Carroll, Colin

AU - Rubia, Katya

AU - McGuire, Philip K.

N1 - Funding Information: This study was supported by grants from the Psychiatry Research Trust, United Kingdom. SB is supported by an MRC Clinical Research Training Fellowship. PFP is supported by the Guy's & St. Thomas' Charitable Foundation, New Services and Innovations in Health Care. All authors have agreed to the submission of this article in this form, and we do not have any conflict interests that might be interpreted as influencing its content.

PY - 2008/12/1

Y1 - 2008/12/1

N2 - Background: This study examined the effect of Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on brain activation during a motor inhibition task. Methods: Functional magnetic resonance imaging and behavioural measures were recorded while 15 healthy volunteers performed a Go/No-Go task following administration of either THC or CBD or placebo in a double-blind, pseudo-randomized, placebo-controlled repeated measures within-subject design. Results: Relative to placebo, THC attenuated activation in the right inferior frontal and the anterior cingulate gyrus. In contrast, CBD deactivated the left temporal cortex and insula. These effects were not related to changes in anxiety, intoxication, sedation, and psychotic symptoms. Conclusions: These data suggest that THC attenuates the engagement of brain regions that mediate response inhibition. CBD modulated function in regions not usually implicated in response inhibition.

AB - Background: This study examined the effect of Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on brain activation during a motor inhibition task. Methods: Functional magnetic resonance imaging and behavioural measures were recorded while 15 healthy volunteers performed a Go/No-Go task following administration of either THC or CBD or placebo in a double-blind, pseudo-randomized, placebo-controlled repeated measures within-subject design. Results: Relative to placebo, THC attenuated activation in the right inferior frontal and the anterior cingulate gyrus. In contrast, CBD deactivated the left temporal cortex and insula. These effects were not related to changes in anxiety, intoxication, sedation, and psychotic symptoms. Conclusions: These data suggest that THC attenuates the engagement of brain regions that mediate response inhibition. CBD modulated function in regions not usually implicated in response inhibition.

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ER -

Neural Basis of Δ-9-Tetrahydrocannabinol and Cannabidiol: Effects During Response Inhibition

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