TY - JOUR
T1 - Neural Basis of Δ-9-Tetrahydrocannabinol and Cannabidiol
T2 - Effects During Response Inhibition
AU - Borgwardt, Stefan J.
AU - Allen, Paul
AU - Bhattacharyya, Sagnik
AU - Fusar-Poli, Paolo
AU - Crippa, Jose A.
AU - Seal, Marc L.
AU - Fraccaro, Valter
AU - Atakan, Zerrin
AU - Martin-Santos, Rocio
AU - O'Carroll, Colin
AU - Rubia, Katya
AU - McGuire, Philip K.
N1 - Funding Information:
This study was supported by grants from the Psychiatry Research Trust, United Kingdom. SB is supported by an MRC Clinical Research Training Fellowship. PFP is supported by the Guy's & St. Thomas' Charitable Foundation, New Services and Innovations in Health Care. All authors have agreed to the submission of this article in this form, and we do not have any conflict interests that might be interpreted as influencing its content.
PY - 2008/12/1
Y1 - 2008/12/1
N2 - Background: This study examined the effect of Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on brain activation during a motor inhibition task. Methods: Functional magnetic resonance imaging and behavioural measures were recorded while 15 healthy volunteers performed a Go/No-Go task following administration of either THC or CBD or placebo in a double-blind, pseudo-randomized, placebo-controlled repeated measures within-subject design. Results: Relative to placebo, THC attenuated activation in the right inferior frontal and the anterior cingulate gyrus. In contrast, CBD deactivated the left temporal cortex and insula. These effects were not related to changes in anxiety, intoxication, sedation, and psychotic symptoms. Conclusions: These data suggest that THC attenuates the engagement of brain regions that mediate response inhibition. CBD modulated function in regions not usually implicated in response inhibition.
AB - Background: This study examined the effect of Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on brain activation during a motor inhibition task. Methods: Functional magnetic resonance imaging and behavioural measures were recorded while 15 healthy volunteers performed a Go/No-Go task following administration of either THC or CBD or placebo in a double-blind, pseudo-randomized, placebo-controlled repeated measures within-subject design. Results: Relative to placebo, THC attenuated activation in the right inferior frontal and the anterior cingulate gyrus. In contrast, CBD deactivated the left temporal cortex and insula. These effects were not related to changes in anxiety, intoxication, sedation, and psychotic symptoms. Conclusions: These data suggest that THC attenuates the engagement of brain regions that mediate response inhibition. CBD modulated function in regions not usually implicated in response inhibition.
UR - http://www.scopus.com/inward/record.url?scp=55349114694&partnerID=8YFLogxK
U2 - 10.1016/j.biopsych.2008.05.011
DO - 10.1016/j.biopsych.2008.05.011
M3 - Journal articles
C2 - 18589404
AN - SCOPUS:55349114694
SN - 0006-3223
VL - 64
SP - 966
EP - 973
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 11
ER -
