Neural Basis of Δ-9-Tetrahydrocannabinol and Cannabidiol: Effects During Response Inhibition

Stefan J. Borgwardt*, Paul Allen, Sagnik Bhattacharyya, Paolo Fusar-Poli, Jose A. Crippa, Marc L. Seal, Valter Fraccaro, Zerrin Atakan, Rocio Martin-Santos, Colin O'Carroll, Katya Rubia, Philip K. McGuire

*Corresponding author for this work
150 Citations (Scopus)


Background: This study examined the effect of Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on brain activation during a motor inhibition task. Methods: Functional magnetic resonance imaging and behavioural measures were recorded while 15 healthy volunteers performed a Go/No-Go task following administration of either THC or CBD or placebo in a double-blind, pseudo-randomized, placebo-controlled repeated measures within-subject design. Results: Relative to placebo, THC attenuated activation in the right inferior frontal and the anterior cingulate gyrus. In contrast, CBD deactivated the left temporal cortex and insula. These effects were not related to changes in anxiety, intoxication, sedation, and psychotic symptoms. Conclusions: These data suggest that THC attenuates the engagement of brain regions that mediate response inhibition. CBD modulated function in regions not usually implicated in response inhibition.

Original languageEnglish
JournalBiological Psychiatry
Issue number11
Pages (from-to)966-973
Number of pages8
Publication statusPublished - 01.12.2008


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