Projects per year
Abstract
Small-vessel vasculitis (SVV) is a chronic autoinflammatory condition linked to antineutrophil cytoplasm autoantibodies (ANCAs). Here we show that chromatin fibers, so-called neutrophil extracellular traps (NETs), are released by ANCA-stimulated neutrophils and contain the targeted autoantigens proteinase-3 (PR3) and myeloperoxidase (MPO). Deposition of NETs in inflamed kidneys and circulating MPO-DNA complexes suggest that NET formation triggers vasculitis and promotes the autoimmune response against neutrophil components in individuals with SVV.
Original language | English |
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Journal | Nature Medicine |
Volume | 15 |
Issue number | 6 |
Pages (from-to) | 623-625 |
Number of pages | 3 |
ISSN | 1078-8956 |
DOIs | |
Publication status | Published - 08.06.2009 |
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)
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Dive into the research topics of 'Netting neutrophils in autoimmune small-vessel vasculitis'. Together they form a unique fingerprint.Projects
- 1 Finished
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CRU 170: Early Pathogenesis of Wegener's Granulomatosis: From Innate Immunity with Granuloma Formation to Autoimmunity.
Gross, W. (Speaker, Coordinator) & Lamprecht, P. (Principal Investigator (PI))
01.01.07 → 31.12.15
Project: DFG Projects › DFG Joint Research: Research Units/Clinical Research Units