Netting neutrophils in autoimmune small-vessel vasculitis

Kai Kessenbrock*, Markus Krumbholz, Ulf Schönermarck, Walter Back, Wolfgang L. Gross, Zena Werb, Hermann Josef Gröne, Volker Brinkmann, Dieter E. Jenne

*Corresponding author for this work
816 Citations (Scopus)


Small-vessel vasculitis (SVV) is a chronic autoinflammatory condition linked to antineutrophil cytoplasm autoantibodies (ANCAs). Here we show that chromatin fibers, so-called neutrophil extracellular traps (NETs), are released by ANCA-stimulated neutrophils and contain the targeted autoantigens proteinase-3 (PR3) and myeloperoxidase (MPO). Deposition of NETs in inflamed kidneys and circulating MPO-DNA complexes suggest that NET formation triggers vasculitis and promotes the autoimmune response against neutrophil components in individuals with SVV.

Original languageEnglish
JournalNature Medicine
Issue number6
Pages (from-to)623-625
Number of pages3
Publication statusPublished - 08.06.2009

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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