Neonatal pemphigus vulgaris: IgG4 autoantibodies to desmoglein 3 induce skin blisters in newborns

Thomas Parlowsky*, Julia Welzel, Masayuki Amagai, Detlef Zillikens, Thorsten Wygold

*Corresponding author for this work
    44 Citations (Scopus)

    Abstract

    We report a case of neonatal pemphigus vulgaris presenting with skin lesions on the head, genital area, and right foot. Pemphigus vulgaris was diagnosed by the presence of circulating autoantibodies predominantly of the IgG4 subtype by indirect immunofluorescence microscopy and by enzyme-linked immunosorbent assay using recombinant desmoglein 3. This case demonstrates the pathogenic relevance of IgG4 autoantibodies to desmoglein 3 in the skin of neonates.

    Original languageEnglish
    JournalJournal of the American Academy of Dermatology
    Volume48
    Issue number4
    Pages (from-to)623-625
    Number of pages3
    ISSN0190-9622
    DOIs
    Publication statusPublished - 01.04.2003

    Fingerprint

    Dive into the research topics of 'Neonatal pemphigus vulgaris: IgG4 autoantibodies to desmoglein 3 induce skin blisters in newborns'. Together they form a unique fingerprint.

    Cite this