Neonatal pemphigus vulgaris: IgG4 autoantibodies to desmoglein 3 induce skin blisters in newborns

Thomas Parlowsky; Julia Welzel; Masayuki Amagai; Detlef Zillikens; Thorsten Wygold

doi:10.1067/mjd.2003.170

Neonatal pemphigus vulgaris: IgG4 autoantibodies to desmoglein 3 induce skin blisters in newborns

Thomas Parlowsky^*, Julia Welzel, Masayuki Amagai, Detlef Zillikens, Thorsten Wygold

^*Corresponding author for this work

Clinic of Dermatology, Allergology and Venerology

Keio University School of Medicine

44 Citations (Scopus)

Abstract

We report a case of neonatal pemphigus vulgaris presenting with skin lesions on the head, genital area, and right foot. Pemphigus vulgaris was diagnosed by the presence of circulating autoantibodies predominantly of the IgG4 subtype by indirect immunofluorescence microscopy and by enzyme-linked immunosorbent assay using recombinant desmoglein 3. This case demonstrates the pathogenic relevance of IgG4 autoantibodies to desmoglein 3 in the skin of neonates.

Original language	English
Journal	Journal of the American Academy of Dermatology
Volume	48
Issue number	4
Pages (from-to)	623-625
Number of pages	3
ISSN	0190-9622
DOIs	https://doi.org/10.1067/mjd.2003.170
Publication status	Published - 01.04.2003

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abstract = "We report a case of neonatal pemphigus vulgaris presenting with skin lesions on the head, genital area, and right foot. Pemphigus vulgaris was diagnosed by the presence of circulating autoantibodies predominantly of the IgG4 subtype by indirect immunofluorescence microscopy and by enzyme-linked immunosorbent assay using recombinant desmoglein 3. This case demonstrates the pathogenic relevance of IgG4 autoantibodies to desmoglein 3 in the skin of neonates.",

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AU - Zillikens, Detlef

AU - Wygold, Thorsten

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AB - We report a case of neonatal pemphigus vulgaris presenting with skin lesions on the head, genital area, and right foot. Pemphigus vulgaris was diagnosed by the presence of circulating autoantibodies predominantly of the IgG4 subtype by indirect immunofluorescence microscopy and by enzyme-linked immunosorbent assay using recombinant desmoglein 3. This case demonstrates the pathogenic relevance of IgG4 autoantibodies to desmoglein 3 in the skin of neonates.

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Neonatal pemphigus vulgaris: IgG4 autoantibodies to desmoglein 3 induce skin blisters in newborns

Abstract

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