Neonatal pemphigus vulgaris: IgG4 autoantibodies to desmoglein 3 induce skin blisters in newborns

Thomas Parlowsky; Julia Welzel; Masayuki Amagai; Detlef Zillikens; Thorsten Wygold

doi:10.1067/mjd.2003.170

Neonatal pemphigus vulgaris: IgG4 autoantibodies to desmoglein 3 induce skin blisters in newborns

Thomas Parlowsky^*, Julia Welzel, Masayuki Amagai, Detlef Zillikens, Thorsten Wygold

^*Corresponding author for this work

44 Citations (Scopus)

Abstract

We report a case of neonatal pemphigus vulgaris presenting with skin lesions on the head, genital area, and right foot. Pemphigus vulgaris was diagnosed by the presence of circulating autoantibodies predominantly of the IgG4 subtype by indirect immunofluorescence microscopy and by enzyme-linked immunosorbent assay using recombinant desmoglein 3. This case demonstrates the pathogenic relevance of IgG4 autoantibodies to desmoglein 3 in the skin of neonates.

Original language	English
Journal	Journal of the American Academy of Dermatology
Volume	48
Issue number	4
Pages (from-to)	623-625
Number of pages	3
ISSN	0190-9622
DOIs	https://doi.org/10.1067/mjd.2003.170
Publication status	Published - 01.04.2003

Access to Document

10.1067/mjd.2003.170

Cite this

@article{9e0fe6b902c04d67b8d454cb94a51a6b,

title = "Neonatal pemphigus vulgaris: IgG4 autoantibodies to desmoglein 3 induce skin blisters in newborns",

abstract = "We report a case of neonatal pemphigus vulgaris presenting with skin lesions on the head, genital area, and right foot. Pemphigus vulgaris was diagnosed by the presence of circulating autoantibodies predominantly of the IgG4 subtype by indirect immunofluorescence microscopy and by enzyme-linked immunosorbent assay using recombinant desmoglein 3. This case demonstrates the pathogenic relevance of IgG4 autoantibodies to desmoglein 3 in the skin of neonates.",

author = "Thomas Parlowsky and Julia Welzel and Masayuki Amagai and Detlef Zillikens and Thorsten Wygold",

year = "2003",

month = apr,

day = "1",

doi = "10.1067/mjd.2003.170",

language = "English",

volume = "48",

pages = "623--625",

journal = "Journal of the American Academy of Dermatology",

issn = "0190-9622",

number = "4",

}

TY - JOUR

T1 - Neonatal pemphigus vulgaris: IgG4 autoantibodies to desmoglein 3 induce skin blisters in newborns

AU - Parlowsky, Thomas

AU - Welzel, Julia

AU - Amagai, Masayuki

AU - Zillikens, Detlef

AU - Wygold, Thorsten

PY - 2003/4/1

Y1 - 2003/4/1

N2 - We report a case of neonatal pemphigus vulgaris presenting with skin lesions on the head, genital area, and right foot. Pemphigus vulgaris was diagnosed by the presence of circulating autoantibodies predominantly of the IgG4 subtype by indirect immunofluorescence microscopy and by enzyme-linked immunosorbent assay using recombinant desmoglein 3. This case demonstrates the pathogenic relevance of IgG4 autoantibodies to desmoglein 3 in the skin of neonates.

AB - We report a case of neonatal pemphigus vulgaris presenting with skin lesions on the head, genital area, and right foot. Pemphigus vulgaris was diagnosed by the presence of circulating autoantibodies predominantly of the IgG4 subtype by indirect immunofluorescence microscopy and by enzyme-linked immunosorbent assay using recombinant desmoglein 3. This case demonstrates the pathogenic relevance of IgG4 autoantibodies to desmoglein 3 in the skin of neonates.

UR - http://www.scopus.com/inward/record.url?scp=0037380309&partnerID=8YFLogxK

U2 - 10.1067/mjd.2003.170

DO - 10.1067/mjd.2003.170

M3 - Journal articles

C2 - 12664033

AN - SCOPUS:0037380309

SN - 0190-9622

VL - 48

SP - 623

EP - 625

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

IS - 4

ER -

Neonatal pemphigus vulgaris: IgG4 autoantibodies to desmoglein 3 induce skin blisters in newborns

Abstract

Access to Document

Other files and links

Fingerprint

Cite this