NCF1 gene and pseudogene pattern: Association with parasitic infection and autoimmunity

Bernhard Greve; Peter Hoffmann; Reinhard Vonthein; Jürgen Kun; Bertrand Lell; Marcin P. Mycko; Krysztof W. Selmaj; Klaus Berger; Robert Weissert; Peter G. Kremsner

doi:10.1186/1475-2875-7-251

NCF1 gene and pseudogene pattern: Association with parasitic infection and autoimmunity

Bernhard Greve^*, Peter Hoffmann, Reinhard Vonthein, Jürgen Kun, Bertrand Lell, Marcin P. Mycko, Krysztof W. Selmaj, Klaus Berger, Robert Weissert, Peter G. Kremsner

^*Corresponding author for this work

Institute of Medical Biometry and Statistic

12 Citations (Scopus)

Abstract

Background. Neutrophil cytosolic factor 1, p47^phox (NCF1) is a component of the leukocyte NADPH oxidase complex mediating formation of reactive oxygen intermediates (ROI) which play an important role in host defense and autoimmunity. An individual genomic pattern of ncf1 and its two types of pseudogenes (reflected by the ΔGT/GTGT ratio) may influence the individual capacity to produce ROI. Methods. NCF1ΔGT/GTGT ratios were correlated with clinical parameters and ROI production during Plasmodium falciparum malaria and with susceptibility to the autoimmune disease multiple sclerosis (MS). Results. Among Gabonese children with severe malaria, ROI production from peripheral blood tended to be higher in individuals with a ΔGT/GTGT ratio ≤ 1:1. ΔGT/GTGT ratios were not associated with susceptibility to MS, but to age-of-onset among MS patients. Conclusion. The genomic pattern of NCF1 and its pseudogenes might influence ROI production but only marginally influence susceptibility to and outcome of malaria and MS.

Original language	English
Article number	251
Journal	Malaria Journal
Volume	7
DOIs	https://doi.org/10.1186/1475-2875-7-251
Publication status	Published - 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1186/1475-2875-7-251

Cite this

@article{0d5bd0e147ec4282a09c1994c74080d2,

title = "NCF1 gene and pseudogene pattern: Association with parasitic infection and autoimmunity",

abstract = "Background. Neutrophil cytosolic factor 1, p47phox (NCF1) is a component of the leukocyte NADPH oxidase complex mediating formation of reactive oxygen intermediates (ROI) which play an important role in host defense and autoimmunity. An individual genomic pattern of ncf1 and its two types of pseudogenes (reflected by the ΔGT/GTGT ratio) may influence the individual capacity to produce ROI. Methods. NCF1ΔGT/GTGT ratios were correlated with clinical parameters and ROI production during Plasmodium falciparum malaria and with susceptibility to the autoimmune disease multiple sclerosis (MS). Results. Among Gabonese children with severe malaria, ROI production from peripheral blood tended to be higher in individuals with a ΔGT/GTGT ratio ≤ 1:1. ΔGT/GTGT ratios were not associated with susceptibility to MS, but to age-of-onset among MS patients. Conclusion. The genomic pattern of NCF1 and its pseudogenes might influence ROI production but only marginally influence susceptibility to and outcome of malaria and MS.",

author = "Bernhard Greve and Peter Hoffmann and Reinhard Vonthein and J{\"u}rgen Kun and Bertrand Lell and Mycko, {Marcin P.} and Selmaj, {Krysztof W.} and Klaus Berger and Robert Weissert and Kremsner, {Peter G.}",

year = "2008",

doi = "10.1186/1475-2875-7-251",

language = "English",

volume = "7",

journal = "Malaria Journal",

issn = "1475-2875",

}

TY - JOUR

T1 - NCF1 gene and pseudogene pattern: Association with parasitic infection and autoimmunity

AU - Greve, Bernhard

AU - Hoffmann, Peter

AU - Vonthein, Reinhard

AU - Kun, Jürgen

AU - Lell, Bertrand

AU - Mycko, Marcin P.

AU - Selmaj, Krysztof W.

AU - Berger, Klaus

AU - Weissert, Robert

AU - Kremsner, Peter G.

PY - 2008

Y1 - 2008

N2 - Background. Neutrophil cytosolic factor 1, p47phox (NCF1) is a component of the leukocyte NADPH oxidase complex mediating formation of reactive oxygen intermediates (ROI) which play an important role in host defense and autoimmunity. An individual genomic pattern of ncf1 and its two types of pseudogenes (reflected by the ΔGT/GTGT ratio) may influence the individual capacity to produce ROI. Methods. NCF1ΔGT/GTGT ratios were correlated with clinical parameters and ROI production during Plasmodium falciparum malaria and with susceptibility to the autoimmune disease multiple sclerosis (MS). Results. Among Gabonese children with severe malaria, ROI production from peripheral blood tended to be higher in individuals with a ΔGT/GTGT ratio ≤ 1:1. ΔGT/GTGT ratios were not associated with susceptibility to MS, but to age-of-onset among MS patients. Conclusion. The genomic pattern of NCF1 and its pseudogenes might influence ROI production but only marginally influence susceptibility to and outcome of malaria and MS.

AB - Background. Neutrophil cytosolic factor 1, p47phox (NCF1) is a component of the leukocyte NADPH oxidase complex mediating formation of reactive oxygen intermediates (ROI) which play an important role in host defense and autoimmunity. An individual genomic pattern of ncf1 and its two types of pseudogenes (reflected by the ΔGT/GTGT ratio) may influence the individual capacity to produce ROI. Methods. NCF1ΔGT/GTGT ratios were correlated with clinical parameters and ROI production during Plasmodium falciparum malaria and with susceptibility to the autoimmune disease multiple sclerosis (MS). Results. Among Gabonese children with severe malaria, ROI production from peripheral blood tended to be higher in individuals with a ΔGT/GTGT ratio ≤ 1:1. ΔGT/GTGT ratios were not associated with susceptibility to MS, but to age-of-onset among MS patients. Conclusion. The genomic pattern of NCF1 and its pseudogenes might influence ROI production but only marginally influence susceptibility to and outcome of malaria and MS.

UR - http://www.scopus.com/inward/record.url?scp=60549098996&partnerID=8YFLogxK

U2 - 10.1186/1475-2875-7-251

DO - 10.1186/1475-2875-7-251

M3 - Journal articles

C2 - 19077231

AN - SCOPUS:60549098996

SN - 1475-2875

VL - 7

JO - Malaria Journal

JF - Malaria Journal

M1 - 251

ER -

NCF1 gene and pseudogene pattern: Association with parasitic infection and autoimmunity

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this