Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging

Anna C. Bakenecker; Anselm von Gladiss; Hannes Schwenke; André Behrends; Thomas Friedrich; Kerstin Lüdtke-Buzug; Alexander Neumann; Joerg Barkhausen; Franz Wegner; Thorsten M. Buzug

doi:10.1038/s41598-021-93323-4

Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging

Anna C. Bakenecker^*, Anselm von Gladiss, Hannes Schwenke, André Behrends, Thomas Friedrich, Kerstin Lüdtke-Buzug, Alexander Neumann, Joerg Barkhausen, Franz Wegner, Thorsten M. Buzug

^*Corresponding author for this work

4 Citations (Scopus)

Abstract

Cerebral aneurysms are potentially life threatening and nowadays treated by a catheter-guided coiling or by a neurosurgical clipping intervention. Here, we propose a helically shaped magnetic micro-robot, which can be steered by magnetic fields in an untethered manner and could be applied for a novel coiling procedure. This is shown by navigating the micro-robot through an additively manufactured phantom of a human cerebral aneurysm. The magnetic fields are applied with a magnetic particle imaging (MPI) scanner, which allows for the navigation and tomographic visualization by the same machine. With MPI the actuation process can be visualized with a localization accuracy of 0.68 mm and an angiogram can be acquired both without any radiation exposure. First in-vitro phantom experiments are presented, showing an idea of a robot conducted treatment of cerebral aneurysms.

Original language	English
Article number	14082
Journal	Scientific Reports
Volume	11
Issue number	1
ISSN	2045-2322
DOIs	https://doi.org/10.1038/s41598-021-93323-4
Publication status	Published - 12.2021

Funding

Open Access funding enabled and organized by Projekt DEAL. The authors gratefully acknowledge the Federal Ministry of Education and Research, Germany (BMBF) for funding this project under Grant Numbers 13GW0230B (FMT), 13GW0069A (SAMBA PATI), 01DL17010A (IMAGINE) and 13GW0071D (SKAMPI).

Research Areas and Centers

Academic Focus: Biomedical Engineering

DFG Research Classification Scheme

2.22-32 Medical Physics, Biomedical Technology
2.22-30 Radiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/s41598-021-93323-4

Cite this

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title = "Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging",

abstract = "Cerebral aneurysms are potentially life threatening and nowadays treated by a catheter-guided coiling or by a neurosurgical clipping intervention. Here, we propose a helically shaped magnetic micro-robot, which can be steered by magnetic fields in an untethered manner and could be applied for a novel coiling procedure. This is shown by navigating the micro-robot through an additively manufactured phantom of a human cerebral aneurysm. The magnetic fields are applied with a magnetic particle imaging (MPI) scanner, which allows for the navigation and tomographic visualization by the same machine. With MPI the actuation process can be visualized with a localization accuracy of 0.68 mm and an angiogram can be acquired both without any radiation exposure. First in-vitro phantom experiments are presented, showing an idea of a robot conducted treatment of cerebral aneurysms.",

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AU - Bakenecker, Anna C.

AU - von Gladiss, Anselm

AU - Schwenke, Hannes

AU - Behrends, André

AU - Friedrich, Thomas

AU - Lüdtke-Buzug, Kerstin

AU - Neumann, Alexander

AU - Barkhausen, Joerg

AU - Wegner, Franz

AU - Buzug, Thorsten M.

PY - 2021/12

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N2 - Cerebral aneurysms are potentially life threatening and nowadays treated by a catheter-guided coiling or by a neurosurgical clipping intervention. Here, we propose a helically shaped magnetic micro-robot, which can be steered by magnetic fields in an untethered manner and could be applied for a novel coiling procedure. This is shown by navigating the micro-robot through an additively manufactured phantom of a human cerebral aneurysm. The magnetic fields are applied with a magnetic particle imaging (MPI) scanner, which allows for the navigation and tomographic visualization by the same machine. With MPI the actuation process can be visualized with a localization accuracy of 0.68 mm and an angiogram can be acquired both without any radiation exposure. First in-vitro phantom experiments are presented, showing an idea of a robot conducted treatment of cerebral aneurysms.

AB - Cerebral aneurysms are potentially life threatening and nowadays treated by a catheter-guided coiling or by a neurosurgical clipping intervention. Here, we propose a helically shaped magnetic micro-robot, which can be steered by magnetic fields in an untethered manner and could be applied for a novel coiling procedure. This is shown by navigating the micro-robot through an additively manufactured phantom of a human cerebral aneurysm. The magnetic fields are applied with a magnetic particle imaging (MPI) scanner, which allows for the navigation and tomographic visualization by the same machine. With MPI the actuation process can be visualized with a localization accuracy of 0.68 mm and an angiogram can be acquired both without any radiation exposure. First in-vitro phantom experiments are presented, showing an idea of a robot conducted treatment of cerebral aneurysms.

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Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging

Abstract

Funding

Research Areas and Centers

DFG Research Classification Scheme

UN SDGs

Access to Document

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