Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging

Anna C. Bakenecker; Anselm von Gladiss; Hannes Schwenke; André Behrends; Thomas Friedrich; Kerstin Lüdtke-Buzug; Alexander Neumann; Joerg Barkhausen; Franz Wegner; Thorsten M. Buzug

doi:10.1038/s41598-021-93323-4

Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging

Anna C. Bakenecker^*, Anselm von Gladiss, Hannes Schwenke, André Behrends, Thomas Friedrich, Kerstin Lüdtke-Buzug, Alexander Neumann, Joerg Barkhausen, Franz Wegner, Thorsten M. Buzug

^*Corresponding author for this work

4 Citations (Scopus)

Abstract

Cerebral aneurysms are potentially life threatening and nowadays treated by a catheter-guided coiling or by a neurosurgical clipping intervention. Here, we propose a helically shaped magnetic micro-robot, which can be steered by magnetic fields in an untethered manner and could be applied for a novel coiling procedure. This is shown by navigating the micro-robot through an additively manufactured phantom of a human cerebral aneurysm. The magnetic fields are applied with a magnetic particle imaging (MPI) scanner, which allows for the navigation and tomographic visualization by the same machine. With MPI the actuation process can be visualized with a localization accuracy of 0.68 mm and an angiogram can be acquired both without any radiation exposure. First in-vitro phantom experiments are presented, showing an idea of a robot conducted treatment of cerebral aneurysms.

Original language	English
Article number	14082
Journal	Scientific Reports
Volume	11
Issue number	1
ISSN	2045-2322
DOIs	https://doi.org/10.1038/s41598-021-93323-4
Publication status	Published - 12.2021

Research Areas and Centers

Academic Focus: Biomedical Engineering

DFG Research Classification Scheme

205-32 Medical Physics, Biomedical Engineering
205-30 Radiology, Nuclear Medicine, Radiation Therapy and Radiobiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41598-021-93323-4

Cite this

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title = "Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging",

abstract = "Cerebral aneurysms are potentially life threatening and nowadays treated by a catheter-guided coiling or by a neurosurgical clipping intervention. Here, we propose a helically shaped magnetic micro-robot, which can be steered by magnetic fields in an untethered manner and could be applied for a novel coiling procedure. This is shown by navigating the micro-robot through an additively manufactured phantom of a human cerebral aneurysm. The magnetic fields are applied with a magnetic particle imaging (MPI) scanner, which allows for the navigation and tomographic visualization by the same machine. With MPI the actuation process can be visualized with a localization accuracy of 0.68 mm and an angiogram can be acquired both without any radiation exposure. First in-vitro phantom experiments are presented, showing an idea of a robot conducted treatment of cerebral aneurysms.",

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AU - Bakenecker, Anna C.

AU - von Gladiss, Anselm

AU - Schwenke, Hannes

AU - Behrends, André

AU - Friedrich, Thomas

AU - Lüdtke-Buzug, Kerstin

AU - Neumann, Alexander

AU - Barkhausen, Joerg

AU - Wegner, Franz

AU - Buzug, Thorsten M.

PY - 2021/12

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N2 - Cerebral aneurysms are potentially life threatening and nowadays treated by a catheter-guided coiling or by a neurosurgical clipping intervention. Here, we propose a helically shaped magnetic micro-robot, which can be steered by magnetic fields in an untethered manner and could be applied for a novel coiling procedure. This is shown by navigating the micro-robot through an additively manufactured phantom of a human cerebral aneurysm. The magnetic fields are applied with a magnetic particle imaging (MPI) scanner, which allows for the navigation and tomographic visualization by the same machine. With MPI the actuation process can be visualized with a localization accuracy of 0.68 mm and an angiogram can be acquired both without any radiation exposure. First in-vitro phantom experiments are presented, showing an idea of a robot conducted treatment of cerebral aneurysms.

AB - Cerebral aneurysms are potentially life threatening and nowadays treated by a catheter-guided coiling or by a neurosurgical clipping intervention. Here, we propose a helically shaped magnetic micro-robot, which can be steered by magnetic fields in an untethered manner and could be applied for a novel coiling procedure. This is shown by navigating the micro-robot through an additively manufactured phantom of a human cerebral aneurysm. The magnetic fields are applied with a magnetic particle imaging (MPI) scanner, which allows for the navigation and tomographic visualization by the same machine. With MPI the actuation process can be visualized with a localization accuracy of 0.68 mm and an angiogram can be acquired both without any radiation exposure. First in-vitro phantom experiments are presented, showing an idea of a robot conducted treatment of cerebral aneurysms.

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Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging

Abstract

Research Areas and Centers

DFG Research Classification Scheme

UN SDGs

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