TY - JOUR
T1 - Natural killer cells in atopic and autoimmune diseases of the skin
AU - von Bubnoff, Dagmar
AU - Andrès, Emmanuel
AU - Hentges, François
AU - Bieber, Thomas
AU - Michel, Tatiana
AU - Zimmer, Jacques
N1 - Funding Information:
Supported by grants from the Ministry of Culture, Higher Education, and Research (MCESR), Luxembourg, and the National Research Fund (FNR), Luxembourg.
Funding Information:
Disclosure of potential conflict of interest: F. Hentges receives research support from Fonds National de la Recherche. J. Zimmer receives research support from Ministry of Research (Luxembourg) and Fonds National de la Recherche (Luxembourg). All other authors declare no conflicts of interest.
PY - 2010/1
Y1 - 2010/1
N2 - Natural killer (NK) cells are best known for their ability to recognize and kill tumor cells and virally infected cells and for their ability to produce large amounts of some cytokines, such as IFN-γ. Recent research has substantially expanded our view on the function of NK cells in the immune system in health and disease. In addition to the better-studied functions in cancer and autoimmunity, contributions from NK cells to allergies and various skin diseases have emerged. We briefly recount the traditional NK cell functions before focusing on their roles in atopic dermatitis, psoriasis, alopecia areata, and pemphigus vulgaris. Although this field is still developing, strong data are available that indicate NK cell involvement. In patients with allergic diseases, the production of TH2 cytokines by NK cells contributes to the known immune deviation. In patients with psoriasis, their pathophysiologic role seems to be especially the production of IFN-γ. NK cell overactivation can be found in patients with alopecia areata and pemphigus vulgaris. Many details are still unclear; however, we believe that there is solid evidence that NK cells actively participate in a number of diseases that have not been traditionally linked to this type of lymphocyte.
AB - Natural killer (NK) cells are best known for their ability to recognize and kill tumor cells and virally infected cells and for their ability to produce large amounts of some cytokines, such as IFN-γ. Recent research has substantially expanded our view on the function of NK cells in the immune system in health and disease. In addition to the better-studied functions in cancer and autoimmunity, contributions from NK cells to allergies and various skin diseases have emerged. We briefly recount the traditional NK cell functions before focusing on their roles in atopic dermatitis, psoriasis, alopecia areata, and pemphigus vulgaris. Although this field is still developing, strong data are available that indicate NK cell involvement. In patients with allergic diseases, the production of TH2 cytokines by NK cells contributes to the known immune deviation. In patients with psoriasis, their pathophysiologic role seems to be especially the production of IFN-γ. NK cell overactivation can be found in patients with alopecia areata and pemphigus vulgaris. Many details are still unclear; however, we believe that there is solid evidence that NK cells actively participate in a number of diseases that have not been traditionally linked to this type of lymphocyte.
UR - http://www.scopus.com/inward/record.url?scp=73349104119&partnerID=8YFLogxK
U2 - 10.1016/j.jaci.2009.11.020
DO - 10.1016/j.jaci.2009.11.020
M3 - Journal articles
C2 - 20109737
AN - SCOPUS:73349104119
SN - 0091-6749
VL - 125
SP - 60
EP - 68
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 1-3
ER -