Myoclonus-dystonia, obsessive-compulsive disorder, and alcohol dependence in SGCE mutation carriers

C. W. Hess; D. Raymond; P. De Carvalho Aguiar; S. Frucht; J. Shriberg; G. A. Heiman; R. Kurlan; C. Klein; S. B. Bressman; L. J. Ozelius; R. Saunders-Pullman

doi:10.1212/01.wnl.0000253188.76092.06

Myoclonus-dystonia, obsessive-compulsive disorder, and alcohol dependence in SGCE mutation carriers

C. W. Hess, D. Raymond, P. De Carvalho Aguiar, S. Frucht, J. Shriberg, G. A. Heiman, R. Kurlan, C. Klein, S. B. Bressman, L. J. Ozelius, R. Saunders-Pullman^*

^*Corresponding author for this work

Institute of Neurogenetics

95 Citations (Scopus)

Abstract

Although myoclonus and dystonia are the hallmarks of myoclonus-dystonia (M-D), psychiatric features, particularly obsessive-compulsive disorder and alcohol dependence, have been reported in three families linked to chromosome 7q21. As the epsilon sarcoglycan (SGCE) gene for M-D was subsequently identified, we evaluated the relationship between psychiatric features and SGCE mutations in these original and two additional families and confirm that OCD and alcohol dependence are associated with manifesting mutated SGCE.

Original language	English
Journal	Neurology
Volume	68
Issue number	7
Pages (from-to)	522-524
Number of pages	3
ISSN	0028-3878
DOIs	https://doi.org/10.1212/01.wnl.0000253188.76092.06
Publication status	Published - 01.02.2007

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title = "Myoclonus-dystonia, obsessive-compulsive disorder, and alcohol dependence in SGCE mutation carriers",

abstract = "Although myoclonus and dystonia are the hallmarks of myoclonus-dystonia (M-D), psychiatric features, particularly obsessive-compulsive disorder and alcohol dependence, have been reported in three families linked to chromosome 7q21. As the epsilon sarcoglycan (SGCE) gene for M-D was subsequently identified, we evaluated the relationship between psychiatric features and SGCE mutations in these original and two additional families and confirm that OCD and alcohol dependence are associated with manifesting mutated SGCE.",

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T1 - Myoclonus-dystonia, obsessive-compulsive disorder, and alcohol dependence in SGCE mutation carriers

AU - Hess, C. W.

AU - Raymond, D.

AU - Aguiar, P. De Carvalho

AU - Frucht, S.

AU - Shriberg, J.

AU - Heiman, G. A.

AU - Kurlan, R.

AU - Klein, C.

AU - Bressman, S. B.

AU - Ozelius, L. J.

AU - Saunders-Pullman, R.

PY - 2007/2/1

Y1 - 2007/2/1

N2 - Although myoclonus and dystonia are the hallmarks of myoclonus-dystonia (M-D), psychiatric features, particularly obsessive-compulsive disorder and alcohol dependence, have been reported in three families linked to chromosome 7q21. As the epsilon sarcoglycan (SGCE) gene for M-D was subsequently identified, we evaluated the relationship between psychiatric features and SGCE mutations in these original and two additional families and confirm that OCD and alcohol dependence are associated with manifesting mutated SGCE.

AB - Although myoclonus and dystonia are the hallmarks of myoclonus-dystonia (M-D), psychiatric features, particularly obsessive-compulsive disorder and alcohol dependence, have been reported in three families linked to chromosome 7q21. As the epsilon sarcoglycan (SGCE) gene for M-D was subsequently identified, we evaluated the relationship between psychiatric features and SGCE mutations in these original and two additional families and confirm that OCD and alcohol dependence are associated with manifesting mutated SGCE.

UR - https://www.scopus.com/pages/publications/33847029189

U2 - 10.1212/01.wnl.0000253188.76092.06

DO - 10.1212/01.wnl.0000253188.76092.06

M3 - Journal articles

C2 - 17296918

AN - SCOPUS:33847029189

SN - 0028-3878

VL - 68

SP - 522

EP - 524

JO - Neurology

JF - Neurology

IS - 7

ER -

Myoclonus-dystonia, obsessive-compulsive disorder, and alcohol dependence in SGCE mutation carriers

Abstract

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