TY - JOUR
T1 - Myoclonus-dystonia, obsessive-compulsive disorder, and alcohol dependence in SGCE mutation carriers
AU - Hess, C. W.
AU - Raymond, D.
AU - Aguiar, P. De Carvalho
AU - Frucht, S.
AU - Shriberg, J.
AU - Heiman, G. A.
AU - Kurlan, R.
AU - Klein, C.
AU - Bressman, S. B.
AU - Ozelius, L. J.
AU - Saunders-Pullman, R.
PY - 2007/2/1
Y1 - 2007/2/1
N2 - Although myoclonus and dystonia are the hallmarks of myoclonus-dystonia (M-D), psychiatric features, particularly obsessive-compulsive disorder and alcohol dependence, have been reported in three families linked to chromosome 7q21. As the epsilon sarcoglycan (SGCE) gene for M-D was subsequently identified, we evaluated the relationship between psychiatric features and SGCE mutations in these original and two additional families and confirm that OCD and alcohol dependence are associated with manifesting mutated SGCE.
AB - Although myoclonus and dystonia are the hallmarks of myoclonus-dystonia (M-D), psychiatric features, particularly obsessive-compulsive disorder and alcohol dependence, have been reported in three families linked to chromosome 7q21. As the epsilon sarcoglycan (SGCE) gene for M-D was subsequently identified, we evaluated the relationship between psychiatric features and SGCE mutations in these original and two additional families and confirm that OCD and alcohol dependence are associated with manifesting mutated SGCE.
UR - http://www.scopus.com/inward/record.url?scp=33847029189&partnerID=8YFLogxK
U2 - 10.1212/01.wnl.0000253188.76092.06
DO - 10.1212/01.wnl.0000253188.76092.06
M3 - Journal articles
C2 - 17296918
AN - SCOPUS:33847029189
SN - 0028-3878
VL - 68
SP - 522
EP - 524
JO - Neurology
JF - Neurology
IS - 7
ER -
