TY - JOUR
T1 - Myocardial infarct
T2 - Depiction with contrast-enhanced MR imaging - Comparison of gadopentetate and gadobenate
AU - Schlosser, Thomas
AU - Hunold, Peter
AU - Herborn, Christoph U.
AU - Lehmkuhl, Heidrun
AU - Lind, Alexander
AU - Massing, Sandra
AU - Barkhausen, Jörg
PY - 2005/9/1
Y1 - 2005/9/1
N2 - Institutional review board approval and patient written informed consent were obtained. On two separate occasions, 24 hours apart, contrast-enhanced cardiac magnetic resonance (MR) imaging was performed prospectively at 1, 3, 5, 10, and 20 minutes after injection of gadopentetate dimeglumine and gadobenate dimeglumine in 15 patients (11 men, four women) with history of myocardial infarction. Both agents allowed detection of infarcted myocardium. T1 values at all times were significantly (P < .05) lower for gadobenate, compared with values for gadopentetate, in both infarcted and noninfarcted myocardium. At 1 minute after administration of both agents, T1 values in left ventricular cavity (LVC) were not different; at 3-20 minutes after injection, values were significantly (P < .05) lower for gadobenate. Differences between contrast-to-noise ratio (CNR) values of infarcted and noninfarcted myocardium were significantly higher on gadobenate-enhanced images (P < .05). CNR values between infarcted myocardium and LVC were significantly higher on gadopentetate-enhanced images (P < .05). Gadopentetate might permit better delineation of infarcts, especially subendocardial infarcts.
AB - Institutional review board approval and patient written informed consent were obtained. On two separate occasions, 24 hours apart, contrast-enhanced cardiac magnetic resonance (MR) imaging was performed prospectively at 1, 3, 5, 10, and 20 minutes after injection of gadopentetate dimeglumine and gadobenate dimeglumine in 15 patients (11 men, four women) with history of myocardial infarction. Both agents allowed detection of infarcted myocardium. T1 values at all times were significantly (P < .05) lower for gadobenate, compared with values for gadopentetate, in both infarcted and noninfarcted myocardium. At 1 minute after administration of both agents, T1 values in left ventricular cavity (LVC) were not different; at 3-20 minutes after injection, values were significantly (P < .05) lower for gadobenate. Differences between contrast-to-noise ratio (CNR) values of infarcted and noninfarcted myocardium were significantly higher on gadobenate-enhanced images (P < .05). CNR values between infarcted myocardium and LVC were significantly higher on gadopentetate-enhanced images (P < .05). Gadopentetate might permit better delineation of infarcts, especially subendocardial infarcts.
UR - http://www.scopus.com/inward/record.url?scp=23844485892&partnerID=8YFLogxK
U2 - 10.1148/radiol.2363040220
DO - 10.1148/radiol.2363040220
M3 - Journal articles
C2 - 16055693
AN - SCOPUS:23844485892
SN - 0033-8419
VL - 236
SP - 1041
EP - 1046
JO - Radiology
JF - Radiology
IS - 3
ER -