Mutual influence of sleep and circadian clocks on physiology and cognition

Isabel Heyde; Jana Thabea Kiehn; Henrik Oster

doi:10.1016/j.freeradbiomed.2017.11.003

Mutual influence of sleep and circadian clocks on physiology and cognition

Isabel Heyde, Jana Thabea Kiehn, Henrik Oster^*

^*Corresponding author for this work

27 Citations (Scopus)

Abstract

The 24-h sleep-wake cycle is one of the most prominent outputs of the circadian clock system. At the same time, changes in sleep-wake behavior feedback on behavioral and physiological circadian rhythms, thus altering the coordination of the body's clock network. Sleep and circadian rhythm disruption have similar physiological endpoints including metabolic, cognitive, and immunologic impairments. This raises the question to which extent these phenomena are causally linked. In this review, we summarize different physiologic outcomes of sleep deprivation and mistimed sleep and discuss the experimental evidence for a mediating role of the circadian clock machinery in this context.

Original language	English
Journal	Free Radical Biology and Medicine
Volume	119
Pages (from-to)	8-16
Number of pages	9
ISSN	0891-5849
DOIs	https://doi.org/10.1016/j.freeradbiomed.2017.11.003
Publication status	Published - 01.05.2018

Funding

This work was funded by the Deutsche Forschungsgemeinschaft (GRK-1957 and TR-SFB-134) and the Volkswagen Foundation (Lichtenberg Program).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 8 Decent Work and Economic Growth
SDG 10 Reduced Inequalities

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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10.1016/j.freeradbiomed.2017.11.003

Cite this

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abstract = "The 24-h sleep-wake cycle is one of the most prominent outputs of the circadian clock system. At the same time, changes in sleep-wake behavior feedback on behavioral and physiological circadian rhythms, thus altering the coordination of the body's clock network. Sleep and circadian rhythm disruption have similar physiological endpoints including metabolic, cognitive, and immunologic impairments. This raises the question to which extent these phenomena are causally linked. In this review, we summarize different physiologic outcomes of sleep deprivation and mistimed sleep and discuss the experimental evidence for a mediating role of the circadian clock machinery in this context.",

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AU - Heyde, Isabel

AU - Kiehn, Jana Thabea

AU - Oster, Henrik

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N2 - The 24-h sleep-wake cycle is one of the most prominent outputs of the circadian clock system. At the same time, changes in sleep-wake behavior feedback on behavioral and physiological circadian rhythms, thus altering the coordination of the body's clock network. Sleep and circadian rhythm disruption have similar physiological endpoints including metabolic, cognitive, and immunologic impairments. This raises the question to which extent these phenomena are causally linked. In this review, we summarize different physiologic outcomes of sleep deprivation and mistimed sleep and discuss the experimental evidence for a mediating role of the circadian clock machinery in this context.

AB - The 24-h sleep-wake cycle is one of the most prominent outputs of the circadian clock system. At the same time, changes in sleep-wake behavior feedback on behavioral and physiological circadian rhythms, thus altering the coordination of the body's clock network. Sleep and circadian rhythm disruption have similar physiological endpoints including metabolic, cognitive, and immunologic impairments. This raises the question to which extent these phenomena are causally linked. In this review, we summarize different physiologic outcomes of sleep deprivation and mistimed sleep and discuss the experimental evidence for a mediating role of the circadian clock machinery in this context.

UR - https://www.scopus.com/pages/publications/85034433532

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DO - 10.1016/j.freeradbiomed.2017.11.003

M3 - Scientific review articles

AN - SCOPUS:85034433532

SN - 0891-5849

VL - 119

SP - 8

EP - 16

JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

ER -

Mutual influence of sleep and circadian clocks on physiology and cognition

Abstract

Funding

UN SDGs

Research Areas and Centers

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