TY - JOUR
T1 - Music-Supported Therapy induces plasticity in the sensorimotor cortex in chronic stroke: A single-case study using multimodal imaging (fMRI-TMS)
AU - Rojo, Nuria
AU - Amengual, Julian
AU - Juncadella, Montserrat
AU - Rubio, Francisco
AU - Camara, Estela
AU - Marco-Pallares, Josep
AU - Schneider, Sabine
AU - Veciana, Misericordia
AU - Montero, Jordi
AU - Mohammadi, Bahram
AU - Altenmüller, Eckart
AU - Grau, Carles
AU - Münte, Thomas F.
AU - Rodriguez-Fornells, Antoni
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Primary objective: Music-Supported Therapy (MST) has been developed recently in order to improve the use of the affected upper extremity after stroke. This study investigated the neuroplastic mechanisms underlying effectiveness in a patient with chronic stroke. Methods: MST uses musical instruments, a midi piano and an electronic drum set emitting piano sounds, to retrain fine and gross movements of the paretic upper extremity. Data are presented from a patient with a chronic stroke (20 months post-stroke) with residual right-sided hemiparesis who took part in 20 MST sessions over the course of 4 weeks. Results: Post-therapy, a marked improvement of movement quality, assessed by 3D movement analysis, was observed. Moreover, functional magnetic resonance imaging (fMRI) of a sequential hand movement revealed distinct therapy-related changes in the form of a reduction of excess contralateral and ipsilateral activations. This was accompanied by changes in cortical excitability evidenced by transcranial magnetic stimulation (TMS). Functional MRI in a music listening task suggests that one of the effects of MST is the task-dependent coupling of auditory and motor cortical areas. Conclusions: The MST appears to be a useful neurorehabilitation tool in patients with chronic stroke and leads to neural reorganization in the sensorimotor cortex.
AB - Primary objective: Music-Supported Therapy (MST) has been developed recently in order to improve the use of the affected upper extremity after stroke. This study investigated the neuroplastic mechanisms underlying effectiveness in a patient with chronic stroke. Methods: MST uses musical instruments, a midi piano and an electronic drum set emitting piano sounds, to retrain fine and gross movements of the paretic upper extremity. Data are presented from a patient with a chronic stroke (20 months post-stroke) with residual right-sided hemiparesis who took part in 20 MST sessions over the course of 4 weeks. Results: Post-therapy, a marked improvement of movement quality, assessed by 3D movement analysis, was observed. Moreover, functional magnetic resonance imaging (fMRI) of a sequential hand movement revealed distinct therapy-related changes in the form of a reduction of excess contralateral and ipsilateral activations. This was accompanied by changes in cortical excitability evidenced by transcranial magnetic stimulation (TMS). Functional MRI in a music listening task suggests that one of the effects of MST is the task-dependent coupling of auditory and motor cortical areas. Conclusions: The MST appears to be a useful neurorehabilitation tool in patients with chronic stroke and leads to neural reorganization in the sensorimotor cortex.
UR - http://www.scopus.com/inward/record.url?scp=79959226050&partnerID=8YFLogxK
U2 - 10.3109/02699052.2011.576305
DO - 10.3109/02699052.2011.576305
M3 - Journal articles
AN - SCOPUS:79959226050
SN - 0269-9052
VL - 25
SP - 787
EP - 793
JO - Brain Injury
JF - Brain Injury
IS - 7-8
ER -