TY - JOUR
T1 - Muscle ultrasonography as an additional diagnostic tool for the diagnosis of amyotrophic lateral sclerosis
AU - Grimm, A.
AU - Prell, T.
AU - Décard, B. F.
AU - Schumacher, U.
AU - Witte, O. W.
AU - Axer, H.
AU - Grosskreutz, J.
N1 - Publisher Copyright:
© 2014 International Federation of Clinical Neurophysiology.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Objective: We aimed to determine the utility of muscle ultrasonography (MUS) in addition to electromyography (EMG) in the diagnosis of amyotrophic lateral sclerosis (ALS). Methods: In all, 60 patients with ALS and 20 with other neuromuscular disorders underwent MUS and EMG. In addition, 30 healthy controls underwent only MUS. Occurrence of fasciculations and fibrillations was evaluated. Ultrasonic echogenicity was graded semiquantitatively. Results: The incidence of fasciculations was significantly higher in patients undergoing MUS than in those undergoing EMG (. p<. 0.05), even in muscles of full strength (. p<. 0.001). However, EMG was more sensitive in detecting fibrillations (. p<. 0.05). MUS had an overall higher sensitivity in detecting spontaneous activity in the tongue (. p<. 0.05). Patients with ALS showed significantly increased muscle echo intensity (EI) compared to patients who were initially suspected as having ALS and normal controls (. p<. 0.05), irrespective of the clinical or electrophysiological status. Conclusion: Our results showed that the sensitivity and specificity of MUS in diagnosing ALS was almost equivalent to those of EMG, using the Awaji criteria. Combination of MUS and EMG enhances the diagnostic accuracy compared to EMG alone (. p<. 0.05). Significance: The combination of EMG and MUS can be used to evaluate the lower motor neuron affection by reducing the use of the often painful and uncomfortable EMG examinations but without decreasing the diagnostic sensitivity and specificity.
AB - Objective: We aimed to determine the utility of muscle ultrasonography (MUS) in addition to electromyography (EMG) in the diagnosis of amyotrophic lateral sclerosis (ALS). Methods: In all, 60 patients with ALS and 20 with other neuromuscular disorders underwent MUS and EMG. In addition, 30 healthy controls underwent only MUS. Occurrence of fasciculations and fibrillations was evaluated. Ultrasonic echogenicity was graded semiquantitatively. Results: The incidence of fasciculations was significantly higher in patients undergoing MUS than in those undergoing EMG (. p<. 0.05), even in muscles of full strength (. p<. 0.001). However, EMG was more sensitive in detecting fibrillations (. p<. 0.05). MUS had an overall higher sensitivity in detecting spontaneous activity in the tongue (. p<. 0.05). Patients with ALS showed significantly increased muscle echo intensity (EI) compared to patients who were initially suspected as having ALS and normal controls (. p<. 0.05), irrespective of the clinical or electrophysiological status. Conclusion: Our results showed that the sensitivity and specificity of MUS in diagnosing ALS was almost equivalent to those of EMG, using the Awaji criteria. Combination of MUS and EMG enhances the diagnostic accuracy compared to EMG alone (. p<. 0.05). Significance: The combination of EMG and MUS can be used to evaluate the lower motor neuron affection by reducing the use of the often painful and uncomfortable EMG examinations but without decreasing the diagnostic sensitivity and specificity.
UR - http://www.scopus.com/inward/record.url?scp=84924809097&partnerID=8YFLogxK
U2 - 10.1016/j.clinph.2014.06.052
DO - 10.1016/j.clinph.2014.06.052
M3 - Journal articles
C2 - 25204706
AN - SCOPUS:84924809097
SN - 1388-2457
VL - 126
SP - 820
EP - 827
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
IS - 4
ER -
