Multiphasic disseminated encephalomyelitis associated with streptococcal infection

Christoph Härtel*, Stefan Schilling, Stefan Gottschalk, Jürgen Sperner

*Corresponding author for this work
6 Citations (Scopus)


Multiphasic disseminated encephalomyelitis (MDEM) is a rare peculiar diagnosis which is defined as acute demyelinating central nervous system disease with relapses occurring only within 4 weeks of initial manifestation. This report describes the case of a 6-year-old boy with MDEM diagnosed by clinical findings and magnetic resonance imaging. The disease had a biphasic evolution, and with a second course of high-dose corticosteroids a complete recovery without further relapse was obtained during the following 18 months. Serological evidence of streptococcal infection as specific trigger for MDEM was given. Thus this report raises the question whether an additional penicillin prophylaxis could be valuable for prevention of streptococcus-associated MDEM relapses.

Original languageEnglish
JournalEuropean Journal of Paediatric Neurology
Issue number6
Pages (from-to)327-329
Number of pages3
Publication statusPublished - 2002

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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