Multidrug- And extensively drug-resistant mycobacterium tuberculosis Beijing Clades, Ukraine, 2015

Matthias Merker; Elena Nikolaevskaya; Thomas A. Kohl; Barbara Molina-Moya; Olha Pavlovska; Patrik Brännberg; Andrii Dudnyk; Valentyna Stokich; Ivan Barilar; Iryna Marynova; Tetiana Filipova; Cristina Prat; Anders Sjöstedt; Jose Dominguez; Olena Rzhepishevska; Stefan Niemann

doi:10.3201/eid2603.190525

Multidrug- And extensively drug-resistant mycobacterium tuberculosis Beijing Clades, Ukraine, 2015

Matthias Merker^*, Elena Nikolaevskaya, Thomas A. Kohl, Barbara Molina-Moya, Olha Pavlovska, Patrik Brännberg, Andrii Dudnyk, Valentyna Stokich, Ivan Barilar, Iryna Marynova, Tetiana Filipova, Cristina Prat, Anders Sjöstedt, Jose Dominguez, Olena Rzhepishevska, Stefan Niemann

^*Corresponding author for this work

Department of Internal Medicine III

28 Citations (Scopus)

Abstract

Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) is an emerging threat to TB control in Ukraine, a country with the third highest XDR TB burden globally. We used whole-genome sequencing of a convenience sample to identify bacterial genetic and patient-related factors associated with MDR/XDR TB in this country. MDR/XDR TB was associated with 3 distinct Mycobacterium tuberculosis complex lineage 2 (Beijing) clades, Europe/Russia W148 outbreak, Central Asia outbreak, and Ukraine outbreak, which comprised 68.9% of all MDR/XDR TB strains from southern Ukraine. MDR/XDR TB was also associated with previous treatment for TB and urban residence. The circulation of Beijing outbreak strains harboring broad drug resistance, coupled with constraints in drug supply and limited availability of phenotypic drug susceptibility testing, needs to be considered when new TB management strategies are implemented in Ukraine.

Original language	English
Journal	Emerging Infectious Diseases
Volume	26
Issue number	3
Pages (from-to)	481-490
Number of pages	10
ISSN	1080-6040
DOIs	https://doi.org/10.3201/eid2603.190525
Publication status	Published - 2020

Funding

by HAIN Lifescience, outside the submitted work; S.N. reports grants from the German Center for Infection Research and the Leibniz Association during the conduct of the study; E.N., I.M., O.P., P.B., J.D., C.P., O.R. report FP7-Marie Curie Sklodowska Actions, grant N 319007, during the study period.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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10.3201/eid2603.190525

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Merker, M., Nikolaevskaya, E., Kohl, T. A., Molina-Moya, B., Pavlovska, O., Brännberg, P., Dudnyk, A., Stokich, V., Barilar, I., Marynova, I., Filipova, T., Prat, C., Sjöstedt, A., Dominguez, J., Rzhepishevska, O., & Niemann, S. (2020). Multidrug- And extensively drug-resistant mycobacterium tuberculosis Beijing Clades, Ukraine, 2015. Emerging Infectious Diseases, 26(3), 481-490. https://doi.org/10.3201/eid2603.190525

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title = "Multidrug- And extensively drug-resistant mycobacterium tuberculosis Beijing Clades, Ukraine, 2015",

abstract = "Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) is an emerging threat to TB control in Ukraine, a country with the third highest XDR TB burden globally. We used whole-genome sequencing of a convenience sample to identify bacterial genetic and patient-related factors associated with MDR/XDR TB in this country. MDR/XDR TB was associated with 3 distinct Mycobacterium tuberculosis complex lineage 2 (Beijing) clades, Europe/Russia W148 outbreak, Central Asia outbreak, and Ukraine outbreak, which comprised 68.9\% of all MDR/XDR TB strains from southern Ukraine. MDR/XDR TB was also associated with previous treatment for TB and urban residence. The circulation of Beijing outbreak strains harboring broad drug resistance, coupled with constraints in drug supply and limited availability of phenotypic drug susceptibility testing, needs to be considered when new TB management strategies are implemented in Ukraine.",

author = "Matthias Merker and Elena Nikolaevskaya and Kohl, \{Thomas A.\} and Barbara Molina-Moya and Olha Pavlovska and Patrik Br{\"a}nnberg and Andrii Dudnyk and Valentyna Stokich and Ivan Barilar and Iryna Marynova and Tetiana Filipova and Cristina Prat and Anders Sj{\"o}stedt and Jose Dominguez and Olena Rzhepishevska and Stefan Niemann",

note = "Funding Information: by HAIN Lifescience, outside the submitted work; S.N. reports grants from the German Center for Infection Research and the Leibniz Association during the conduct of the study; E.N., I.M., O.P., P.B., J.D., C.P., O.R. report FP7-Marie Curie Sklodowska Actions, grant N 319007, during the study period. Publisher Copyright: {\textcopyright} 2020 Centers for Disease Control and Prevention (CDC). All rights reserved. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

doi = "10.3201/eid2603.190525",

language = "English",

volume = "26",

pages = "481--490",

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Merker, M, Nikolaevskaya, E, Kohl, TA, Molina-Moya, B, Pavlovska, O, Brännberg, P, Dudnyk, A, Stokich, V, Barilar, I, Marynova, I, Filipova, T, Prat, C, Sjöstedt, A, Dominguez, J, Rzhepishevska, O & Niemann, S 2020, 'Multidrug- And extensively drug-resistant mycobacterium tuberculosis Beijing Clades, Ukraine, 2015', Emerging Infectious Diseases, vol. 26, no. 3, pp. 481-490. https://doi.org/10.3201/eid2603.190525

TY - JOUR

T1 - Multidrug- And extensively drug-resistant mycobacterium tuberculosis Beijing Clades, Ukraine, 2015

AU - Merker, Matthias

AU - Nikolaevskaya, Elena

AU - Kohl, Thomas A.

AU - Molina-Moya, Barbara

AU - Pavlovska, Olha

AU - Brännberg, Patrik

AU - Dudnyk, Andrii

AU - Stokich, Valentyna

AU - Barilar, Ivan

AU - Marynova, Iryna

AU - Filipova, Tetiana

AU - Prat, Cristina

AU - Sjöstedt, Anders

AU - Dominguez, Jose

AU - Rzhepishevska, Olena

AU - Niemann, Stefan

N1 - Funding Information: by HAIN Lifescience, outside the submitted work; S.N. reports grants from the German Center for Infection Research and the Leibniz Association during the conduct of the study; E.N., I.M., O.P., P.B., J.D., C.P., O.R. report FP7-Marie Curie Sklodowska Actions, grant N 319007, during the study period. Publisher Copyright: © 2020 Centers for Disease Control and Prevention (CDC). All rights reserved. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020

Y1 - 2020

N2 - Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) is an emerging threat to TB control in Ukraine, a country with the third highest XDR TB burden globally. We used whole-genome sequencing of a convenience sample to identify bacterial genetic and patient-related factors associated with MDR/XDR TB in this country. MDR/XDR TB was associated with 3 distinct Mycobacterium tuberculosis complex lineage 2 (Beijing) clades, Europe/Russia W148 outbreak, Central Asia outbreak, and Ukraine outbreak, which comprised 68.9% of all MDR/XDR TB strains from southern Ukraine. MDR/XDR TB was also associated with previous treatment for TB and urban residence. The circulation of Beijing outbreak strains harboring broad drug resistance, coupled with constraints in drug supply and limited availability of phenotypic drug susceptibility testing, needs to be considered when new TB management strategies are implemented in Ukraine.

AB - Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) is an emerging threat to TB control in Ukraine, a country with the third highest XDR TB burden globally. We used whole-genome sequencing of a convenience sample to identify bacterial genetic and patient-related factors associated with MDR/XDR TB in this country. MDR/XDR TB was associated with 3 distinct Mycobacterium tuberculosis complex lineage 2 (Beijing) clades, Europe/Russia W148 outbreak, Central Asia outbreak, and Ukraine outbreak, which comprised 68.9% of all MDR/XDR TB strains from southern Ukraine. MDR/XDR TB was also associated with previous treatment for TB and urban residence. The circulation of Beijing outbreak strains harboring broad drug resistance, coupled with constraints in drug supply and limited availability of phenotypic drug susceptibility testing, needs to be considered when new TB management strategies are implemented in Ukraine.

UR - https://www.scopus.com/pages/publications/85079912250

U2 - 10.3201/eid2603.190525

DO - 10.3201/eid2603.190525

M3 - Journal articles

C2 - 32091369

AN - SCOPUS:85079912250

SN - 1080-6040

VL - 26

SP - 481

EP - 490

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 3

ER -

Multidrug- And extensively drug-resistant mycobacterium tuberculosis Beijing Clades, Ukraine, 2015

Abstract

Funding

UN SDGs

Research Areas and Centers

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