TY - JOUR
T1 - Multidrug- And extensively drug-resistant mycobacterium tuberculosis Beijing Clades, Ukraine, 2015
AU - Merker, Matthias
AU - Nikolaevskaya, Elena
AU - Kohl, Thomas A.
AU - Molina-Moya, Barbara
AU - Pavlovska, Olha
AU - Brännberg, Patrik
AU - Dudnyk, Andrii
AU - Stokich, Valentyna
AU - Barilar, Ivan
AU - Marynova, Iryna
AU - Filipova, Tetiana
AU - Prat, Cristina
AU - Sjöstedt, Anders
AU - Dominguez, Jose
AU - Rzhepishevska, Olena
AU - Niemann, Stefan
N1 - Funding Information:
by HAIN Lifescience, outside the submitted work; S.N. reports grants from the German Center for Infection Research and the Leibniz Association during the conduct of the study; E.N., I.M., O.P., P.B., J.D., C.P., O.R. report FP7-Marie Curie Sklodowska Actions, grant N 319007, during the study period.
Publisher Copyright:
© 2020 Centers for Disease Control and Prevention (CDC). All rights reserved.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020
Y1 - 2020
N2 - Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) is an emerging threat to TB control in Ukraine, a country with the third highest XDR TB burden globally. We used whole-genome sequencing of a convenience sample to identify bacterial genetic and patient-related factors associated with MDR/XDR TB in this country. MDR/XDR TB was associated with 3 distinct Mycobacterium tuberculosis complex lineage 2 (Beijing) clades, Europe/Russia W148 outbreak, Central Asia outbreak, and Ukraine outbreak, which comprised 68.9% of all MDR/XDR TB strains from southern Ukraine. MDR/XDR TB was also associated with previous treatment for TB and urban residence. The circulation of Beijing outbreak strains harboring broad drug resistance, coupled with constraints in drug supply and limited availability of phenotypic drug susceptibility testing, needs to be considered when new TB management strategies are implemented in Ukraine.
AB - Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) is an emerging threat to TB control in Ukraine, a country with the third highest XDR TB burden globally. We used whole-genome sequencing of a convenience sample to identify bacterial genetic and patient-related factors associated with MDR/XDR TB in this country. MDR/XDR TB was associated with 3 distinct Mycobacterium tuberculosis complex lineage 2 (Beijing) clades, Europe/Russia W148 outbreak, Central Asia outbreak, and Ukraine outbreak, which comprised 68.9% of all MDR/XDR TB strains from southern Ukraine. MDR/XDR TB was also associated with previous treatment for TB and urban residence. The circulation of Beijing outbreak strains harboring broad drug resistance, coupled with constraints in drug supply and limited availability of phenotypic drug susceptibility testing, needs to be considered when new TB management strategies are implemented in Ukraine.
UR - http://www.scopus.com/inward/record.url?scp=85079912250&partnerID=8YFLogxK
U2 - 10.3201/eid2603.190525
DO - 10.3201/eid2603.190525
M3 - Journal articles
C2 - 32091369
AN - SCOPUS:85079912250
SN - 1080-6040
VL - 26
SP - 481
EP - 490
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 3
ER -
