Multi-shot Diffusion EPI Reconstruction with Iterative Rigid Motion-correction and Motion-induced Phase-correction for Brain Imaging

Multi-shot diffusion-weighted imaging offers increased SNR and higher resolution, but makes the acquisition vulnerable to shot-specific phase variations and macroscopic inter-shot motion. A wide range of iterative phase-corrected reconstruction schemes have been proposed to overcome the inter-shot phase inconsistencies, but robust motion estimation is still challenging due to the inherently low SNR of DWI. This work moves forward from initial one-time rigid motion estimation to an alternating optimization balancing the joint image, phase and motion estimation. A novel multi-shot echo-planar diffusion algorithm with iterative motion and phase correction is presented in simulations and in-vivo.