MtDNA sequence, phylogeny and evolution of laboratory mice

Junfeng Zheng; Yan Chen; Fengyuan Deng; Renliang Huang; Frank Petersen; Saleh Ibrahim; Xinhua Yu

doi:10.1016/j.mito.2014.07.006

MtDNA sequence, phylogeny and evolution of laboratory mice

Junfeng Zheng, Yan Chen, Fengyuan Deng, Renliang Huang, Frank Petersen, Saleh Ibrahim, Xinhua Yu^*

^*Corresponding author for this work

Clinic of Dermatology, Allergology and Venerology

3 Citations (Scopus)

Abstract

Laboratory mice are important tools for biomedical research. Aiming to investigate the phylogeny and evolution of laboratory mice, we investigated the mtDNA sequences of classic inbred strains, classic outbred stocks and wild-derived inbred strains. Our results showed that the most classic outbred stocks and classic inbred strains are descended from a single mtDNA ancestor. The phylogenic analysis supports the topology of M. m. castaneus/. M. m. domesticus as sister subspecies, and the divergence time between the two sister subspecies and M. m. musculus was 493,000 (435,000-557,000) years ago. Furthermore, the mtDNA polymorphisms accumulated in the last 100. years in the laboratory mice are under a relaxed purifying selection.

Original language	English
Journal	Mitochondrion
Volume	17
Pages (from-to)	126-131
Number of pages	6
ISSN	1567-7249
DOIs	https://doi.org/10.1016/j.mito.2014.07.006
Publication status	Published - 07.2014

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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10.1016/j.mito.2014.07.006

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title = "MtDNA sequence, phylogeny and evolution of laboratory mice",

abstract = "Laboratory mice are important tools for biomedical research. Aiming to investigate the phylogeny and evolution of laboratory mice, we investigated the mtDNA sequences of classic inbred strains, classic outbred stocks and wild-derived inbred strains. Our results showed that the most classic outbred stocks and classic inbred strains are descended from a single mtDNA ancestor. The phylogenic analysis supports the topology of M. m. castaneus/. M. m. domesticus as sister subspecies, and the divergence time between the two sister subspecies and M. m. musculus was 493,000 (435,000-557,000) years ago. Furthermore, the mtDNA polymorphisms accumulated in the last 100. years in the laboratory mice are under a relaxed purifying selection.",

author = "Junfeng Zheng and Yan Chen and Fengyuan Deng and Renliang Huang and Frank Petersen and Saleh Ibrahim and Xinhua Yu",

note = "Funding Information: This work was supported by the National Natural Science Foundation of China (No. 81371325 ).",

year = "2014",

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T1 - MtDNA sequence, phylogeny and evolution of laboratory mice

AU - Zheng, Junfeng

AU - Chen, Yan

AU - Deng, Fengyuan

AU - Huang, Renliang

AU - Petersen, Frank

AU - Ibrahim, Saleh

AU - Yu, Xinhua

N1 - Funding Information: This work was supported by the National Natural Science Foundation of China (No. 81371325 ).

PY - 2014/7

Y1 - 2014/7

N2 - Laboratory mice are important tools for biomedical research. Aiming to investigate the phylogeny and evolution of laboratory mice, we investigated the mtDNA sequences of classic inbred strains, classic outbred stocks and wild-derived inbred strains. Our results showed that the most classic outbred stocks and classic inbred strains are descended from a single mtDNA ancestor. The phylogenic analysis supports the topology of M. m. castaneus/. M. m. domesticus as sister subspecies, and the divergence time between the two sister subspecies and M. m. musculus was 493,000 (435,000-557,000) years ago. Furthermore, the mtDNA polymorphisms accumulated in the last 100. years in the laboratory mice are under a relaxed purifying selection.

AB - Laboratory mice are important tools for biomedical research. Aiming to investigate the phylogeny and evolution of laboratory mice, we investigated the mtDNA sequences of classic inbred strains, classic outbred stocks and wild-derived inbred strains. Our results showed that the most classic outbred stocks and classic inbred strains are descended from a single mtDNA ancestor. The phylogenic analysis supports the topology of M. m. castaneus/. M. m. domesticus as sister subspecies, and the divergence time between the two sister subspecies and M. m. musculus was 493,000 (435,000-557,000) years ago. Furthermore, the mtDNA polymorphisms accumulated in the last 100. years in the laboratory mice are under a relaxed purifying selection.

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ER -

MtDNA sequence, phylogeny and evolution of laboratory mice

Abstract

Research Areas and Centers

UN SDGs

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