Purpose: MR-based attenuation correction (AC) will become an integral part of combined PET/MR systems. Here, we propose a toolbox to validate MR-AC of clinical PET/MRI data sets. Methods: Torso scans of ten patients were acquired on a combined PET/CT and on a 1.5-T MRI system. MR-based attenuation data were derived from the CT following MR-CT image co-registration and subsequent histogram matching. PET images were reconstructed after CT- (PETCT) and MR-based AC (PETMRI). Lesion-to-background (L/B) ratios were estimated on PETCT and PETMRI. Results: MR-CT histogram matching leads to a mean voxel intensity difference in the CT- and MR-based attenuation images of 12% (max). Mean differences between PETMRI and PETCT were 19% (max). L/B ratios were similar except for the lung where local misregistration and intensity transformation leads to a biased PETMRI. Conclusion: Our toolbox can be used to study pitfalls in MR-AC. We found that co-registration accuracy and pixel value transformation determine the accuracy of PETMRI.
|European journal of nuclear medicine and molecular imaging
|Number of pages
|Published - 06.2008