TY - JOUR
T1 - Moxonidine displays a presynaptic alpha-2-adrenoceptor-dependent synergistic sympathoinhibitory action at imidazoline-1 receptors
AU - Schäfer, Ulrich
AU - Burgdorf, Christof
AU - Engelhardt, Astrid
AU - Raasch, Walter
AU - Kurz, Thomas
AU - Richardt, Gert
PY - 2003
Y1 - 2003
N2 - The function of presynaptic imidazoline-1 receptors (I1-R) in the heart remains unclear. In rat hearts, UK14.304 and moxonidine reduced norepinephrine (NE) release. AGN192403 had no influence on NE, whereas rilmenidine, agmatine, rauwolscine, and efaroxan increased NE. These effects of moxonidine and rilmenidine were not affected by AGN192403 adminstration. Conversely, after pretreatment with UK14.304, only moxonidine displayed a pronounced inhibitory action on NE release (sensitive to AGN192403), indicating a synergistic inhibitory action at I1-R under conditions of a stimulated alpha2-adrenergic autoinhibition.
AB - The function of presynaptic imidazoline-1 receptors (I1-R) in the heart remains unclear. In rat hearts, UK14.304 and moxonidine reduced norepinephrine (NE) release. AGN192403 had no influence on NE, whereas rilmenidine, agmatine, rauwolscine, and efaroxan increased NE. These effects of moxonidine and rilmenidine were not affected by AGN192403 adminstration. Conversely, after pretreatment with UK14.304, only moxonidine displayed a pronounced inhibitory action on NE release (sensitive to AGN192403), indicating a synergistic inhibitory action at I1-R under conditions of a stimulated alpha2-adrenergic autoinhibition.
U2 - 10.1196/annals.1304.033
DO - 10.1196/annals.1304.033
M3 - Journal articles
C2 - 15028597
SN - 0077-8923
VL - 1009
SP - 265
EP - 269
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
ER -
