Monitoring temperature induced phase changes in subcutaneous fatty tissue using an astigmatism corrected dynamic needle probe

H. Schulz-Hildebrandt; N. Meyer-Schell; M. Casper; M. Evers; R. Birngruber; D. Manstein; G. Hüttmann

doi:10.1117/12.2527087

Monitoring temperature induced phase changes in subcutaneous fatty tissue using an astigmatism corrected dynamic needle probe

H. Schulz-Hildebrandt, N. Meyer-Schell, M. Casper, M. Evers, R. Birngruber, D. Manstein, G. Hüttmann

Institute of Biomedical Optics

Harvard University

Abstract

Cryolipolysis has become a popular non-invasive method of reducing excess fat by cooling. However, the results vary as metabolism, gender and diet may affect the freezing point of human subcutaneous fat. To increase the success for all patients, it is essential to better understand the process of cryolipolysis in vivo. Therefore, we have developed a side-facing needle probe with an outer diameter of 390 μm achieving a lateral resolution of 10 μm at a working distance of 1.5 mm. To obtain a spatially resolved visualization of the immediate processes involve in cryolipolysis, cross-sectional images was obtained by moving the needle probe back and forth in a transparent catheter. At the tip, the transparent catheter was equipped with a lancet for smoothly penetrating through the skin. By a rigorous design including optical wave simulation and by a careful combination of different materials astigmatic aberrations were avoided. Ex vivo measurements on subcutaneous porcine fat were performed to confirm, that imaging with the needle probe is a suitable method for investigating phase changes.

Original language	English
Title of host publication	Clinical and Preclinical Optical Diagnostics II
Editors	J. Quincy Brown, Ton G. van Leeuwen
Number of pages	3
Volume	11073
Publisher	SPIE
Publication date	19.07.2019
Article number	110730L
ISBN (Print)	978-151062839-7
DOIs	https://doi.org/10.1117/12.2527087
Publication status	Published - 19.07.2019
Event	Clinical and Preclinical Optical Diagnostics II 2019 - Munich, Germany Duration: 23.06.2019 → 25.06.2019 Conference number: 152307

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Academic Focus: Biomedical Engineering

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Schulz-Hildebrandt, H., Meyer-Schell, N., Casper, M., Evers, M., Birngruber, R., Manstein, D., & Hüttmann, G. (2019). Monitoring temperature induced phase changes in subcutaneous fatty tissue using an astigmatism corrected dynamic needle probe. In J. Q. Brown, & T. G. van Leeuwen (Eds.), Clinical and Preclinical Optical Diagnostics II (Vol. 11073). Article 110730L (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11073). SPIE. https://doi.org/10.1117/12.2527087

Schulz-Hildebrandt, H. ; Meyer-Schell, N. ; Casper, M. et al. / Monitoring temperature induced phase changes in subcutaneous fatty tissue using an astigmatism corrected dynamic needle probe. Clinical and Preclinical Optical Diagnostics II. editor / J. Quincy Brown ; Ton G. van Leeuwen. Vol. 11073 SPIE, 2019. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

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title = "Monitoring temperature induced phase changes in subcutaneous fatty tissue using an astigmatism corrected dynamic needle probe",

abstract = "Cryolipolysis has become a popular non-invasive method of reducing excess fat by cooling. However, the results vary as metabolism, gender and diet may affect the freezing point of human subcutaneous fat. To increase the success for all patients, it is essential to better understand the process of cryolipolysis in vivo. Therefore, we have developed a side-facing needle probe with an outer diameter of 390 μm achieving a lateral resolution of 10 μm at a working distance of 1.5 mm. To obtain a spatially resolved visualization of the immediate processes involve in cryolipolysis, cross-sectional images was obtained by moving the needle probe back and forth in a transparent catheter. At the tip, the transparent catheter was equipped with a lancet for smoothly penetrating through the skin. By a rigorous design including optical wave simulation and by a careful combination of different materials astigmatic aberrations were avoided. Ex vivo measurements on subcutaneous porcine fat were performed to confirm, that imaging with the needle probe is a suitable method for investigating phase changes.",

author = "H. Schulz-Hildebrandt and N. Meyer-Schell and M. Casper and M. Evers and R. Birngruber and D. Manstein and G. H{\"u}ttmann",

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doi = "10.1117/12.2527087",

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Schulz-Hildebrandt, H, Meyer-Schell, N, Casper, M, Evers, M, Birngruber, R, Manstein, D & Hüttmann, G 2019, Monitoring temperature induced phase changes in subcutaneous fatty tissue using an astigmatism corrected dynamic needle probe. in JQ Brown & TG van Leeuwen (eds), Clinical and Preclinical Optical Diagnostics II. vol. 11073, 110730L, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11073, SPIE, Clinical and Preclinical Optical Diagnostics II 2019, Munich, Bavaria, Germany, 23.06.19. https://doi.org/10.1117/12.2527087

Monitoring temperature induced phase changes in subcutaneous fatty tissue using an astigmatism corrected dynamic needle probe. / Schulz-Hildebrandt, H.; Meyer-Schell, N.; Casper, M. et al.
Clinical and Preclinical Optical Diagnostics II. ed. / J. Quincy Brown; Ton G. van Leeuwen. Vol. 11073 SPIE, 2019. 110730L (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11073).

Research output: Chapters in Books/Reports/Conference Proceedings › Conference contribution › peer-review

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AU - Birngruber, R.

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AU - Hüttmann, G.

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AB - Cryolipolysis has become a popular non-invasive method of reducing excess fat by cooling. However, the results vary as metabolism, gender and diet may affect the freezing point of human subcutaneous fat. To increase the success for all patients, it is essential to better understand the process of cryolipolysis in vivo. Therefore, we have developed a side-facing needle probe with an outer diameter of 390 μm achieving a lateral resolution of 10 μm at a working distance of 1.5 mm. To obtain a spatially resolved visualization of the immediate processes involve in cryolipolysis, cross-sectional images was obtained by moving the needle probe back and forth in a transparent catheter. At the tip, the transparent catheter was equipped with a lancet for smoothly penetrating through the skin. By a rigorous design including optical wave simulation and by a careful combination of different materials astigmatic aberrations were avoided. Ex vivo measurements on subcutaneous porcine fat were performed to confirm, that imaging with the needle probe is a suitable method for investigating phase changes.

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T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

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ER -

Schulz-Hildebrandt H, Meyer-Schell N, Casper M, Evers M, Birngruber R, Manstein D et al. Monitoring temperature induced phase changes in subcutaneous fatty tissue using an astigmatism corrected dynamic needle probe. In Brown JQ, van Leeuwen TG, editors, Clinical and Preclinical Optical Diagnostics II. Vol. 11073. SPIE. 2019. 110730L. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2527087

Monitoring temperature induced phase changes in subcutaneous fatty tissue using an astigmatism corrected dynamic needle probe

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