Molecular Recognition of UDP-Gal by β-1,4-Galactosyltransferase T1

Thorsten Biet, Thomas Peters*

*Corresponding author for this work
30 Citations (Scopus)


Saturation transfer difference (STD) NMR experiments reveal the binding epitopes of UDP-Gal and UDP-Glc bound to the glycosyltransferase β4Gal-T1 (see picture). Whereas the enzyme recognizes the galactose residue in UDP-Gal, it does not make any close contacts with the glucose residue in UDP-Glc. This observation explains why β4Gal-T1 binds to UDP-Glc but is unable to transfer glucose to an acceptor substrate.

Original languageEnglish
JournalAngewandte Chemie - International Edition
Issue number22
Pages (from-to)4189-4192
Number of pages4
Publication statusPublished - 19.11.2001

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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