TY - JOUR
T1 - Molecular mechanisms in allergy and clinical immunology: Antigen-presenting cells in allergy
AU - Von Bubnoff, Dagmar
AU - Geiger, Elisabeth
AU - Bieber, Thomas
N1 - Funding Information:
Supported by a grant from Merck & Co, Inc, West Point, Pa
Funding Information:
Supported by grants of the Deutsche Forschungsgemeinschaft (DFG)(RE 1350/1-1, SFB284/C8 and FOR 367/1-1).
PY - 2001
Y1 - 2001
N2 - The complex interaction of the innate and adaptive immune system requires flexibility and cooperation among various cell types. In this regard, antigen-presenting, cells (APCs) play a pivotal role in transferring information from the periphery of the organism to lymphoid organs, where they initiate the activation of naive T cells. Dendritic cells, Langerhans' cells (LCs), and macrophages are also critical in the induction of allergic inflammation by presenting allergens to T lymphocytes and by contributing to the local recruitment of effector cells. Because of a complex genetic background, atopic individuals exhibit a dysregulation of T cell-mediated immune mechanisms. Attempts to understand the role APCs play in these pathophysiologic conditions are in progress and may allow development of new treatment strategies. In this review we will focus on the biology of APCs and their unique role in the induction and control of allergic inflammation.
AB - The complex interaction of the innate and adaptive immune system requires flexibility and cooperation among various cell types. In this regard, antigen-presenting, cells (APCs) play a pivotal role in transferring information from the periphery of the organism to lymphoid organs, where they initiate the activation of naive T cells. Dendritic cells, Langerhans' cells (LCs), and macrophages are also critical in the induction of allergic inflammation by presenting allergens to T lymphocytes and by contributing to the local recruitment of effector cells. Because of a complex genetic background, atopic individuals exhibit a dysregulation of T cell-mediated immune mechanisms. Attempts to understand the role APCs play in these pathophysiologic conditions are in progress and may allow development of new treatment strategies. In this review we will focus on the biology of APCs and their unique role in the induction and control of allergic inflammation.
UR - http://www.scopus.com/inward/record.url?scp=0035459690&partnerID=8YFLogxK
U2 - 10.1067/mai.2001.117457
DO - 10.1067/mai.2001.117457
M3 - Journal articles
C2 - 11544450
AN - SCOPUS:0035459690
SN - 0091-6749
VL - 108
SP - 329
EP - 339
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 3
ER -