TY - JOUR
T1 - Molecular details of the recognition of blood group antigens by a human norovirus as determined by STD NMR spectroscopy
AU - Fiege, Brigitte
AU - Rademacher, Christoph
AU - Cartmell, Jonathan
AU - Kitov, Pavel I.
AU - Parra, Francisco
AU - Peters, Thomas
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2012/1/23
Y1 - 2012/1/23
N2 - Tracing the infection: The binding of human norovirus particles to blood group antigens was investigated using NMR spectroscopy. Binding epitopes were determined at atomic resolution, information on the binding specificity was obtained, and the bioactive conformation of various sugars was revealed. This provides valuable information for the design of entry inhibitors against this important class of human pathogenic viruses.
AB - Tracing the infection: The binding of human norovirus particles to blood group antigens was investigated using NMR spectroscopy. Binding epitopes were determined at atomic resolution, information on the binding specificity was obtained, and the bioactive conformation of various sugars was revealed. This provides valuable information for the design of entry inhibitors against this important class of human pathogenic viruses.
UR - http://www.scopus.com/inward/record.url?scp=84856006189&partnerID=8YFLogxK
U2 - 10.1002/anie.201105719
DO - 10.1002/anie.201105719
M3 - Journal articles
C2 - 22170811
AN - SCOPUS:84856006189
SN - 1433-7851
VL - 51
SP - 928
EP - 932
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 4
ER -
