Molecular cartography in acute Chlamydia pneumoniae infections - A non-targeted metabolomics approach

Constanze Müller, Inga Dietz, Dimitrios Tziotis, Franco Moritz, Jan Rupp, Philippe Schmitt-Kopplin*

*Corresponding author for this work
    16 Citations (Scopus)


    Infections with Chlamydia pneumoniae cause several respiratory diseases, such as community-acquired pneumonia, bronchitis or sinusitis. Here, we present an integrated non-targeted metabolomics analysis applying ultra-high-resolution mass spectrometry and ultra-performance liquid chromatography mass spectrometry to determine metabolite alterations in C. pneumoniae-infected HEp-2 cells. Most important permutations are elaborated using uni- and multivariate statistical analysis, logD retention time regression and mass defect-based network analysis. Classes of metabolites showing high variations upon infection are lipids, carbohydrates and amino acids. Moreover, we observed several non-annotated compounds as predominantly abundant after infection, which are promising biomarker candidates for drug-target and diagnostic research.

    Original languageEnglish
    JournalAnalytical and Bioanalytical Chemistry
    Issue number15
    Pages (from-to)5119-5131
    Number of pages13
    Publication statusPublished - 01.06.2013

    Research Areas and Centers

    • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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