Modelling the Progression of Brain Metastases

The present work is devoted to model the progression of brain metastases. Without any treatment, the prognosis for patients with brain metastases is poor. Radiosurgery has shown to significantly increase the average survival of patients. To this end, maximization of tumour control while minimizing normal tissue toxicity necessitates an accurate knowledge about the tumour infiltration. Mathematical models of tumour progression potentially provide valuable and complementary information for physicians about the non-detectable part of metastatic lesions. Ultimatively, this information could enable the possibility to improve treatment strategies.