Abstract
The migration of lymphocytes through secondary lymphoid organs was believed to be mainly controlled by chemokine gradients. This theory has recently been called into question since naive lymphocytes observed in vivo by two-photon microscopy show no evidence of directed migration. We have constructed a simple mathematical model of naive T cell migration in lymph nodes that is solely based on local mechanisms. The model was validated against findings from histological analysis and experimentally determined lymphocyte recirculation kinetics. Our results suggest that T cell compartmentalization in lymph nodes can be explained without long-range chemokine gradients. However, the T cell residence time predicted by our model is significantly lower than observed in vivo, indicating the existence of a mechanism which alters the T cell random walk over time.
Original language | English |
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Title of host publication | ICARIS 2007: Artificial Immune Systems |
Editors | Leandro Nunes de Castro, Fernando José Von Zuben, Helder Knidel |
Number of pages | 12 |
Volume | 4628 LNCS |
Publisher | Springer-Verlag Berlin Heidelberg |
Publication date | 2007 |
Pages | 228-239 |
ISBN (Print) | 978-3-540-73921-0 |
ISBN (Electronic) | 978-3-540-73922-7 |
DOIs | |
Publication status | Published - 2007 |
Event | 6th International Conference on Artificial Immune Systems - Santos, Brazil Duration: 26.08.2007 → 29.08.2007 Conference number: 70790 |
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)