Model-based reconstruction for magnetic particle imaging

Tobias Knopp*, Timo F. Sattel, Sven Biederer, Jrgen Rahmer, Jürgen Weizenecker, Bernhard Gleich, Jörn Borgert, Thorsten M. Buzug

*Corresponding author for this work
74 Citations (Scopus)


Magnetic particle imaging (MPI) is a new imaging modality capable of imaging distributions of superparamagnetic nanoparticles with high sensitivity, high spatial resolution and, in particular, high imaging speed. The image reconstruction process requires a system function, describing the mapping between particle distribution and acquired signal. To date, the system function is acquired in a tedious calibration procedure by sequentially measuring the signal of a delta sample at the positions of a grid that covers the field of view. In this work, for the first time, the system function is calculated using a model of the signal chain. The modeled system function allows for reconstruction of the particle distribution in a 1-D MPI experiment. The approach thus enables fast generation of system functions on arbitrarily dense grids. Furthermore, reduction in memory requirements may be feasible by generating parts of the system function on the fly during reconstruction instead of keeping the complete matrix in memory.

Original languageEnglish
Article number4912405
JournalIEEE Transactions on Medical Imaging
Issue number1
Pages (from-to)12-18
Number of pages7
Publication statusPublished - 01.01.2010


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