Model-based analysis and optimization of pressure-controlled ventilation of COPD patients in relation to BMI Model-based optimization of pressure-controlled ventilation of COPD patients

Carlotta Hennigs*, Kai Brehmer, Tim Tristan Hardel, Philipp Rostalski

*Corresponding author for this work

Abstract

This article presents an approach for model-based and personalized determination of inspiratory pressure and inspiratory time in pressure-controlled ventilation. Lung mechanics are strongly dependent on weight and affected by lung diseases such as COPD. Based on a simplified model of the lung with weight- and COPD-specific parameter selection and consideration of ventilation guidelines, the appropriate inspiratory pressure values are calculated. The results illustrate the effect of BMI on the computed optimal pressure-volume ratio. The findings provide a first step towards individualized decision support systems taking into account additional effects like BMI and specific lung diseases.

Original languageEnglish
JournalAt-Automatisierungstechnik
Volume70
Issue number11
Pages (from-to)957-967
Number of pages11
ISSN0178-2312
DOIs
Publication statusPublished - 01.11.2022

Research Areas and Centers

  • Academic Focus: Biomedical Engineering
  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)

DFG Research Classification Scheme

  • 205-13 Pneumology, Thoracal Surgery
  • 407-06 Biomedical Systems Technology

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