Mobilization of iron from cellular ferritin by ascorbic acid in neuroblastoma SK-N-SH cells: An EPR study

S. L. Baader; E. Bill; A. X. Trautwein; G. Bruchelt; B. F. Matzanke

doi:10.1016/0014-5793(96)00098-1

Mobilization of iron from cellular ferritin by ascorbic acid in neuroblastoma SK-N-SH cells: An EPR study

S. L. Baader, E. Bill, A. X. Trautwein, G. Bruchelt, B. F. Matzanke^*

^*Corresponding author for this work

Institute of Physics

28 Citations (Scopus)

Abstract

The mobilization of iron from intracellular ferritin by ascorbic acid has been analysed in situ by electron paramagnetic resonance (EPR) spectroscopy. EPR enables a distinction between ferritins and other Fe³⁺-binding cellular components. The ordered iron core of ferritin gives rise to a resonance signal which can be observed only at temperatures above 50 K. In the present study we clearly demonstrate that ascorbic acid is capable of mobilizing iron from ferritin in the cellular system by reduction of the ferric ion core in neuroblastoma SK-N-SH cells. This mechanism may open new nays in the therapy of this hardly curable tumor in stage IV, especially in combination with some cytostatic drugs.

Original language	English
Journal	FEBS Letters
Volume	381
Issue number	1-2
Pages (from-to)	131-134
Number of pages	4
ISSN	0014-5793
DOIs	https://doi.org/10.1016/0014-5793(96)00098-1
Publication status	Published - 26.02.1996

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title = "Mobilization of iron from cellular ferritin by ascorbic acid in neuroblastoma SK-N-SH cells: An EPR study",

abstract = "The mobilization of iron from intracellular ferritin by ascorbic acid has been analysed in situ by electron paramagnetic resonance (EPR) spectroscopy. EPR enables a distinction between ferritins and other Fe3+-binding cellular components. The ordered iron core of ferritin gives rise to a resonance signal which can be observed only at temperatures above 50 K. In the present study we clearly demonstrate that ascorbic acid is capable of mobilizing iron from ferritin in the cellular system by reduction of the ferric ion core in neuroblastoma SK-N-SH cells. This mechanism may open new nays in the therapy of this hardly curable tumor in stage IV, especially in combination with some cytostatic drugs.",

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T1 - Mobilization of iron from cellular ferritin by ascorbic acid in neuroblastoma SK-N-SH cells: An EPR study

AU - Baader, S. L.

AU - Bill, E.

AU - Trautwein, A. X.

AU - Bruchelt, G.

AU - Matzanke, B. F.

PY - 1996/2/26

Y1 - 1996/2/26

N2 - The mobilization of iron from intracellular ferritin by ascorbic acid has been analysed in situ by electron paramagnetic resonance (EPR) spectroscopy. EPR enables a distinction between ferritins and other Fe3+-binding cellular components. The ordered iron core of ferritin gives rise to a resonance signal which can be observed only at temperatures above 50 K. In the present study we clearly demonstrate that ascorbic acid is capable of mobilizing iron from ferritin in the cellular system by reduction of the ferric ion core in neuroblastoma SK-N-SH cells. This mechanism may open new nays in the therapy of this hardly curable tumor in stage IV, especially in combination with some cytostatic drugs.

AB - The mobilization of iron from intracellular ferritin by ascorbic acid has been analysed in situ by electron paramagnetic resonance (EPR) spectroscopy. EPR enables a distinction between ferritins and other Fe3+-binding cellular components. The ordered iron core of ferritin gives rise to a resonance signal which can be observed only at temperatures above 50 K. In the present study we clearly demonstrate that ascorbic acid is capable of mobilizing iron from ferritin in the cellular system by reduction of the ferric ion core in neuroblastoma SK-N-SH cells. This mechanism may open new nays in the therapy of this hardly curable tumor in stage IV, especially in combination with some cytostatic drugs.

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Mobilization of iron from cellular ferritin by ascorbic acid in neuroblastoma SK-N-SH cells: An EPR study

Abstract

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