Minimal important change and responsiveness of the Migraine Disability Assessment Score (MIDAS) questionnaire

Gabriela F. Carvalho*, Kerstin Luedtke, Tobias Braun

*Corresponding author for this work
12 Citations (Scopus)


Background: The MIDAS is the most used questionnaire to evaluate migraine-related disability, but its utility to assess treatment response remains unclear. Our aim was to estimate the MIDAS’ minimal important change (MIC) value and its responsiveness. Methods: A total of 103 patients were enrolled in a non-pharmacological, preference-based clinical trial. MIDAS and global rating of self-perceived change (GRoC) scores were collected at baseline, after 5 weeks of treatment, 4-weeks and 3-months follow-up after treatment. Anchor-based approaches were used to establish MIC values and responsiveness. Findings: In all 3 timepoint comparisons, MIDAS presented a MIC of 4.5 points. A moderate positive correlation was identified between the MIDAS change and GRoC scores. The area under the curve ranged from 0.63 to 0.68. Conclusions: This study showed that MIDAS has a limited responsiveness to change. A change of 4.5 points or more represents a clinically important change for patients with high frequent migraine and chronic migraine receiving non-pharmacological treatment.

Original languageEnglish
Article number126
JournalJournal of Headache and Pain
Issue number1
Publication statusPublished - 12.2021

Research Areas and Centers

  • Health Sciences

DFG Research Classification Scheme

  • 205-01 Epidemiology, Medical Biometrics/Statistics
  • 206-07 Clinical Neurology Neurosurgery and Neuroradiology

Cite this