Mind the gap: The mismatch between clinical and imaging metrics in ALS

Esther Verstraete; Martin R. Turner; Julian Grosskreutz; Massimo Filippi; Michael Benatar

doi:10.3109/21678421.2015.1051989

Mind the gap: The mismatch between clinical and imaging metrics in ALS

Esther Verstraete^*, Martin R. Turner, Julian Grosskreutz, Massimo Filippi, Michael Benatar

^*Corresponding author for this work

74 Citations (Scopus)

Abstract

Advanced magnetic resonance imaging (MRI) techniques hold the promise to capture upper motor neuron loss and extramotor brain changes in amyotrophic lateral sclerosis (ALS) and as such deliver biomarkers relevant to diagnosis, prognosis and monitoring disease progression. However, a correlation between imaging parameters and clinical metrics has thus far been inconsistent across studies. We discuss the contributing factors to this clinical-imaging correlation gap as well as its implications for future research.

Original language	English
Journal	Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Volume	16
Issue number	7-8
Pages (from-to)	524-529
Number of pages	6
ISSN	2167-8421
DOIs	https://doi.org/10.3109/21678421.2015.1051989
Publication status	Published - 27.11.2015
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Centers: Center for Neuromuscular Diseases

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10.3109/21678421.2015.1051989

Cite this

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AB - Advanced magnetic resonance imaging (MRI) techniques hold the promise to capture upper motor neuron loss and extramotor brain changes in amyotrophic lateral sclerosis (ALS) and as such deliver biomarkers relevant to diagnosis, prognosis and monitoring disease progression. However, a correlation between imaging parameters and clinical metrics has thus far been inconsistent across studies. We discuss the contributing factors to this clinical-imaging correlation gap as well as its implications for future research.

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Mind the gap: The mismatch between clinical and imaging metrics in ALS

Abstract

UN SDGs

Research Areas and Centers

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