TY - JOUR
T1 - Microstructural Organization of Cerebellar Tracts in Schizophrenia
AU - Kanaan, Richard A.A.
AU - Borgwardt, Stefan
AU - McGuire, Philip K.
AU - Craig, Michael C.
AU - Murphy, Declan G.M.
AU - Picchioni, Marco
AU - Shergill, Sukhwinder S.
AU - Jones, Derek K.
AU - Catani, Marco
N1 - Funding Information:
RAAK, MP, and SSS were sponsored by the Wellcome Trust. SB was sponsored by the Swiss National Science Foundation and the Novartis Foundation. MCC and MC were partially supported by the Medical Research Council, UK Autism Multi-Centre Imaging Study network, and the National Division of the South London and Maudsley NHS Foundation Trust.
Funding Information:
PKM has received honoraria for lectures and consultancy fees from Lilly, AstraZeneca, Bristol-Myers Squibb, and Janssen Cilag. SSS has received honoraria or support to attend conferences from Janssen Cilag, Lilly, Novartis, and Sanofi Synthelabo and unrestricted project grant support from Novartis and AstraZeneca. The other authors report no biomedical financial interests or potential conflicts of interest.
PY - 2009/12/1
Y1 - 2009/12/1
N2 - Background: Dysconnectivity theories of schizophrenia would suggest that the connectivity of the cerebellum is impaired and that the impairment may be restricted to certain tracts. Attempts to examine the structural connectivity of the cerebellum using diffusion tensor imaging have yielded conflicting results. However, previous studies have employed region-of-interest approaches or have used small or unmatched samples, with a consequent risk of type II error. Methods: We conducted an appropriately powered case-control study of 33 patients with schizophrenia and 33 matched healthy control subjects. We used tractography to dissect the four white matter tracts of the cerebellum and measured fractional anisotropy (FA) and mean diffusivity (MD) over each tract for each subject. Results: Repeated-measures analysis of variance found that FA was lower in the schizophrenia group compared with the control group, but there were no tract-specific differences between the groups. Mean diffusivity did not differ between the groups. Conclusions: Though structural connectivity is impaired in the cerebellum, it is not local to any particular tract but appears to have a wider, possibly global, distribution. Reduced fractional anisotropy with normal MD would point to the differences being due to disordered neuronal architecture rather than disordered myelination.
AB - Background: Dysconnectivity theories of schizophrenia would suggest that the connectivity of the cerebellum is impaired and that the impairment may be restricted to certain tracts. Attempts to examine the structural connectivity of the cerebellum using diffusion tensor imaging have yielded conflicting results. However, previous studies have employed region-of-interest approaches or have used small or unmatched samples, with a consequent risk of type II error. Methods: We conducted an appropriately powered case-control study of 33 patients with schizophrenia and 33 matched healthy control subjects. We used tractography to dissect the four white matter tracts of the cerebellum and measured fractional anisotropy (FA) and mean diffusivity (MD) over each tract for each subject. Results: Repeated-measures analysis of variance found that FA was lower in the schizophrenia group compared with the control group, but there were no tract-specific differences between the groups. Mean diffusivity did not differ between the groups. Conclusions: Though structural connectivity is impaired in the cerebellum, it is not local to any particular tract but appears to have a wider, possibly global, distribution. Reduced fractional anisotropy with normal MD would point to the differences being due to disordered neuronal architecture rather than disordered myelination.
UR - http://www.scopus.com/inward/record.url?scp=70350721658&partnerID=8YFLogxK
U2 - 10.1016/j.biopsych.2009.07.028
DO - 10.1016/j.biopsych.2009.07.028
M3 - Journal articles
C2 - 19733836
AN - SCOPUS:70350721658
SN - 0006-3223
VL - 66
SP - 1067
EP - 1069
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 11
ER -