MicroRNAs and Their Impact on Radiotherapy for Cancer

Ann Kathrin Mueller; Kirsten Lindner; Richard Hummel; Jörg Haier; David I. Watson; Damian J. Hussey

doi:10.1667/RR14370.1

MicroRNAs and Their Impact on Radiotherapy for Cancer

Ann Kathrin Mueller, Kirsten Lindner, Richard Hummel, Jörg Haier, David I. Watson, Damian J. Hussey^*

^*Corresponding author for this work

Department of Surgery

32 Citations (Scopus)

Abstract

Resistance to radiation is considered to be an important reason for local failure after radiotherapy and tumor recurrence. However, the exact mechanisms of tumor resistance remain poorly understood. Current investigations of microRNAs as potential diagnostic and therapeutic tools for cancer treatment have shown promising results. With respect to radiotherapy resistance and response, there is now emerging evidence that microRNAs modulate key cellular pathways that mediate response to radiation. These data suggest that microRNAs might have significant potential as targets for the development of new therapeutic strategies to overcome radioresistance in cancer. This review summarizes the current literature pertinent to the influence of microRNAs in the response to radiotherapy for cancer treatment, with an emphasis on microRNAs as novel diagnostic and prognostic markers, as well as their potential to alter radiosensitivity.

Original language	English
Journal	Radiation Research
Volume	185
Issue number	6
Pages (from-to)	668-677
Number of pages	10
ISSN	0033-7587
DOIs	https://doi.org/10.1667/RR14370.1
Publication status	Published - 01.06.2016

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Research Area: Luebeck Integrated Oncology Network (LION)

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10.1667/RR14370.1

Cite this

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title = "MicroRNAs and Their Impact on Radiotherapy for Cancer",

abstract = "Resistance to radiation is considered to be an important reason for local failure after radiotherapy and tumor recurrence. However, the exact mechanisms of tumor resistance remain poorly understood. Current investigations of microRNAs as potential diagnostic and therapeutic tools for cancer treatment have shown promising results. With respect to radiotherapy resistance and response, there is now emerging evidence that microRNAs modulate key cellular pathways that mediate response to radiation. These data suggest that microRNAs might have significant potential as targets for the development of new therapeutic strategies to overcome radioresistance in cancer. This review summarizes the current literature pertinent to the influence of microRNAs in the response to radiotherapy for cancer treatment, with an emphasis on microRNAs as novel diagnostic and prognostic markers, as well as their potential to alter radiosensitivity.",

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year = "2016",

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T1 - MicroRNAs and Their Impact on Radiotherapy for Cancer

AU - Mueller, Ann Kathrin

AU - Lindner, Kirsten

AU - Hummel, Richard

AU - Haier, Jörg

AU - Watson, David I.

AU - Hussey, Damian J.

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Resistance to radiation is considered to be an important reason for local failure after radiotherapy and tumor recurrence. However, the exact mechanisms of tumor resistance remain poorly understood. Current investigations of microRNAs as potential diagnostic and therapeutic tools for cancer treatment have shown promising results. With respect to radiotherapy resistance and response, there is now emerging evidence that microRNAs modulate key cellular pathways that mediate response to radiation. These data suggest that microRNAs might have significant potential as targets for the development of new therapeutic strategies to overcome radioresistance in cancer. This review summarizes the current literature pertinent to the influence of microRNAs in the response to radiotherapy for cancer treatment, with an emphasis on microRNAs as novel diagnostic and prognostic markers, as well as their potential to alter radiosensitivity.

AB - Resistance to radiation is considered to be an important reason for local failure after radiotherapy and tumor recurrence. However, the exact mechanisms of tumor resistance remain poorly understood. Current investigations of microRNAs as potential diagnostic and therapeutic tools for cancer treatment have shown promising results. With respect to radiotherapy resistance and response, there is now emerging evidence that microRNAs modulate key cellular pathways that mediate response to radiation. These data suggest that microRNAs might have significant potential as targets for the development of new therapeutic strategies to overcome radioresistance in cancer. This review summarizes the current literature pertinent to the influence of microRNAs in the response to radiotherapy for cancer treatment, with an emphasis on microRNAs as novel diagnostic and prognostic markers, as well as their potential to alter radiosensitivity.

UR - https://www.scopus.com/pages/publications/84976499396

U2 - 10.1667/RR14370.1

DO - 10.1667/RR14370.1

M3 - Scientific review articles

C2 - 27223830

AN - SCOPUS:84976499396

SN - 0033-7587

VL - 185

SP - 668

EP - 677

JO - Radiation Research

JF - Radiation Research

IS - 6

ER -

MicroRNAs and Their Impact on Radiotherapy for Cancer

Abstract

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MicroRNAs As Modifiers Of Drug Resistance In Esophageal Cancer: Impact of Modulation Of Resistance-Relevant MicroRNAs And Their Direct Targets On Chemotherapy

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MicroRNAs and Their Impact on Radiotherapy for Cancer

Abstract

UN SDGs

Research Areas and Centers

Access to Document

Other files and links

Fingerprint

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MicroRNAs As Modifiers Of Drug Resistance In Esophageal Cancer: Impact of Modulation Of Resistance-Relevant MicroRNAs And Their Direct Targets On Chemotherapy

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