MicroRNA signatures in subtypes of follicular lymphoma

Niklas Gebauer*, Wiebke Gollub, Bjorn Stassek, Veronica Bernard, Dirk Rades, Alfred C. Feller, Christoph Thorns

*Corresponding author for this work
6 Citations (Scopus)

Abstract

Background: MicroRNAs are regulators of gene expression implicated in vital cellular processes including differentiation, cell growth and apoptosis. Distinct microRNA signatures have been identified for many malignancies including follicular lymphoma (FL). However, no microRNA expression profile characteristic of FL subtypes, e.g. FL with B-cell lymphoma-6 (BCL6) locus rearrangement (FLBCL2+/BCL6+, FLBCL2-/BCL6+) or FL with diffuse growth pattern have been reported. Materials and Methods: MicroRNA signatures from 44 cases of FL were generated employing a quantitative real-time polymerase chain reaction approach. 15 cases of diffuse FL and 15 cases of FLBCL2+/BCL6+/FLBCL2-/BCL6+ were compared against 14 cases of typical FLBCL2+/BCL6-. Results: Numerous microRNAs were found to be differentially expressed between FLBCL2+/BCL6+ and FLBCL2-/BCL6+, as well as diffuse FL, when compared to typical cases of FL. Up-regulation of several oncogenic microRNAs as well as down-regulation of tumor-suppressor microRNAs was identified. Cluster analysis, however, revealed no microRNA signatures distinct from the reference group for either subtype. Conclusion: These results indicate an involvement of microRNAs in the pathogenesis of FL and its subtypes. Marked de-regulation of oncogenic RNAs and tumor suppressors appears to correspond with a more aggressive phenotype frequently observed in FLBCL2+/BCL6+, FLBCL2-/BCL6+ and diffuse FL.

Original languageEnglish
JournalAnticancer Research
Volume34
Issue number5
Pages (from-to)2105-2112
Number of pages8
ISSN0250-7005
Publication statusPublished - 01.05.2014

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