Abstract
Background: Approximately 20–30 % of patients diagnosed with renal cell carcinoma have metastases at the time of diagnosis. The risk for the development of metastatic renal cell carcinoma for this malignant disease is approximately 55 %.
Objective: Metastasectomy in renal cell carcinoma, especially for lung and liver metastases, can result in a cure in individual cases and results in superior survival rates than systemic therapy alone. This paper gives a current overview of the surgical options for the treatment of metastatic renal cell carcinoma.
Material and methods: This article is based on a selective literature search in the PubMed database on the topic of metastasectomy in renal cell carcinoma.
Results and discussion: The 5-year overall survival rate for multimodal surgical procedures is approximately 40–50 % compared to 20–35 % for systemic therapy alone. The estimation of the prognosis for systemic therapy depends on the risk profiling carried out using various classification systems. Metastasectomy, particularly of solitary tumor manifestations and complete resection of the metastatic lesions, is associated with a superior clinical prognosis for individual patients compared to systemic treatment using targeted therapy alone.
| Translated title of the contribution | Metastasectomy in renal cell carcinoma |
|---|---|
| Original language | German |
| Journal | Onkologe |
| Volume | 21 |
| Issue number | 1 |
| Pages (from-to) | 28-34 |
| Number of pages | 7 |
| ISSN | 0947-8965 |
| DOIs | |
| Publication status | Published - 01.2014 |
Research Areas and Centers
- Research Area: Luebeck Integrated Oncology Network (LION)
