Metallophilic macrophages are lacking in the thymus of lymphotoxin-β receptor-deficient mice

Novica M. Milićević*, Klaus Nohroudi, Milica Labudović-Borović, Živana Milićević, Klaus Pfeffer, Jürgen Westermann

*Corresponding author for this work
12 Citations (Scopus)


Lymphotoxin-β receptor (LTβR) axis plays a crucial role in development and compartmentalization of peripheral lymphatic organs. But, it is also required for the appropriate function and maintenance of structural integrity of the thymus: in LTβR-deficient animals the clonal deletion of autoreactive lymphocytes is impaired and differentiation of thymic medullary epithelial cells is disturbed. In this study, using several markers, we showed that thymic metallophilic macrophages were lacking in LTβR-deficient mice. In tumor necrosis factor receptor-I (p55)-deficient mice (which we used as positive control) thymic metallophilic cells were located, similarly as in normal mice, in the thymic cortico-medullary zone at the junction of cortex and medulla. These findings show that LTβR is necessary for maintenance of metallophilic macrophages in the thymus and provide further evidence that these cells may represent a factor involved in thymic negative selection.

Original languageEnglish
JournalHistochemistry and Cell Biology
Issue number6
Pages (from-to)687-693
Number of pages7
Publication statusPublished - 12.2006

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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