Metabolomics in Cell Biology

Zuhal Eraslan, Marta Cascante, Ulrich L. Günther*

*Corresponding author for this work
3 Citations (Scopus)

Abstract

Metabolomics has long been used in a biomedical context. The most typical samples are body fluids in which small molecules can be detected and quantified using technologies such as Nuclear Magnetic Resonance (NMR) and Mass Spectrometry (MS). Many studies, in particular in the wider field of cancer research, are based on cellular models. Different cancer cells can have vastly different ways of regulating metabolism and responses to drug treatments depend on specific metabolic mechanisms which are often cell type specific. This has led to a series of publications using metabolomics to study metabolic mechanisms. Cell-based metabolomics has specific requirements and allows for interesting approaches where metabolism is followed in real-time. Here applications of metabolomics in cell biology have been reviewed, providing insight into specific technologies used and showing exemplary case studies with an emphasis towards applications which help to understand drug mechanisms.

Original languageEnglish
Title of host publicationHandbook of Experimental Pharmacology
Number of pages27
PublisherSpringer Science and Business Media Deutschland GmbH
Publication date2023
Pages181-207
DOIs
Publication statusPublished - 2023

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

DFG Research Classification Scheme

  • 205-17 Endocrinology, Diabetology, Metabolism
  • 201-03 Cell Biology

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