Metabolic syndrome in patients with myotonic dystrophy type 1

Milorad Vujnic; Stojan Peric; Srdjan Popovic; Nela Raseta; Vesna Ralic; Valerija Dobricic; Ivana Novakovic; Vidosava Rakocevic-Stojanovic

doi:10.1002/mus.24540

Metabolic syndrome in patients with myotonic dystrophy type 1

Milorad Vujnic, Stojan Peric^*, Srdjan Popovic, Nela Raseta, Vesna Ralic, Valerija Dobricic, Ivana Novakovic, Vidosava Rakocevic-Stojanovic

^*Corresponding author for this work

Institute of Neurogenetics

19 Citations (Scopus)

Abstract

Introduction: The aim of this study was to assess the frequency and features of metabolic syndrome (MetS) in myotonic dystrophy type 1 (DM1). Methods: We studied 66 DM1 patients (50% men, aged 41.9±10.5 years, disease duration of 19.3±8.6 years). New worldwide consensus criteria for MetS from 2009 were used. Results: Components of MetS were present at the following frequencies: hypertriglyceridemia 67%; low HDL cholesterol 35%; hypertension 18%; central obesity 14%; and hyperglycemia 9%. MetS was present in 11 (17%) patients. The presence of MetS was not associated with patients' gender, age, disease severity, disease duration, or CTG repeat length (P>0.05). Patients with MetS had significantly lower total SF-36 scores as a measure of quality of life in comparison to patients without MetS (P<0.05). Conclusion: Although certain components of MetS were very frequent in patients with DM1, only 17% met the criteria for MetS.

Original language	English
Journal	Muscle and Nerve
Volume	52
Issue number	2
Pages (from-to)	273-277
Number of pages	5
ISSN	0148-639X
DOIs	https://doi.org/10.1002/mus.24540
Publication status	Published - 01.08.2015

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title = "Metabolic syndrome in patients with myotonic dystrophy type 1",

abstract = "Introduction: The aim of this study was to assess the frequency and features of metabolic syndrome (MetS) in myotonic dystrophy type 1 (DM1). Methods: We studied 66 DM1 patients (50% men, aged 41.9±10.5 years, disease duration of 19.3±8.6 years). New worldwide consensus criteria for MetS from 2009 were used. Results: Components of MetS were present at the following frequencies: hypertriglyceridemia 67%; low HDL cholesterol 35%; hypertension 18%; central obesity 14%; and hyperglycemia 9%. MetS was present in 11 (17%) patients. The presence of MetS was not associated with patients' gender, age, disease severity, disease duration, or CTG repeat length (P>0.05). Patients with MetS had significantly lower total SF-36 scores as a measure of quality of life in comparison to patients without MetS (P<0.05). Conclusion: Although certain components of MetS were very frequent in patients with DM1, only 17% met the criteria for MetS.",

author = "Milorad Vujnic and Stojan Peric and Srdjan Popovic and Nela Raseta and Vesna Ralic and Valerija Dobricic and Ivana Novakovic and Vidosava Rakocevic-Stojanovic",

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AU - Vujnic, Milorad

AU - Peric, Stojan

AU - Popovic, Srdjan

AU - Raseta, Nela

AU - Ralic, Vesna

AU - Dobricic, Valerija

AU - Novakovic, Ivana

AU - Rakocevic-Stojanovic, Vidosava

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Introduction: The aim of this study was to assess the frequency and features of metabolic syndrome (MetS) in myotonic dystrophy type 1 (DM1). Methods: We studied 66 DM1 patients (50% men, aged 41.9±10.5 years, disease duration of 19.3±8.6 years). New worldwide consensus criteria for MetS from 2009 were used. Results: Components of MetS were present at the following frequencies: hypertriglyceridemia 67%; low HDL cholesterol 35%; hypertension 18%; central obesity 14%; and hyperglycemia 9%. MetS was present in 11 (17%) patients. The presence of MetS was not associated with patients' gender, age, disease severity, disease duration, or CTG repeat length (P>0.05). Patients with MetS had significantly lower total SF-36 scores as a measure of quality of life in comparison to patients without MetS (P<0.05). Conclusion: Although certain components of MetS were very frequent in patients with DM1, only 17% met the criteria for MetS.

AB - Introduction: The aim of this study was to assess the frequency and features of metabolic syndrome (MetS) in myotonic dystrophy type 1 (DM1). Methods: We studied 66 DM1 patients (50% men, aged 41.9±10.5 years, disease duration of 19.3±8.6 years). New worldwide consensus criteria for MetS from 2009 were used. Results: Components of MetS were present at the following frequencies: hypertriglyceridemia 67%; low HDL cholesterol 35%; hypertension 18%; central obesity 14%; and hyperglycemia 9%. MetS was present in 11 (17%) patients. The presence of MetS was not associated with patients' gender, age, disease severity, disease duration, or CTG repeat length (P>0.05). Patients with MetS had significantly lower total SF-36 scores as a measure of quality of life in comparison to patients without MetS (P<0.05). Conclusion: Although certain components of MetS were very frequent in patients with DM1, only 17% met the criteria for MetS.

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JO - Muscle and Nerve

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Metabolic syndrome in patients with myotonic dystrophy type 1

Abstract

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