Metabolic syndrome in patients with myotonic dystrophy type 1

Milorad Vujnic, Stojan Peric*, Srdjan Popovic, Nela Raseta, Vesna Ralic, Valerija Dobricic, Ivana Novakovic, Vidosava Rakocevic-Stojanovic

*Corresponding author for this work
    19 Citations (Scopus)

    Abstract

    Introduction: The aim of this study was to assess the frequency and features of metabolic syndrome (MetS) in myotonic dystrophy type 1 (DM1). Methods: We studied 66 DM1 patients (50% men, aged 41.9±10.5 years, disease duration of 19.3±8.6 years). New worldwide consensus criteria for MetS from 2009 were used. Results: Components of MetS were present at the following frequencies: hypertriglyceridemia 67%; low HDL cholesterol 35%; hypertension 18%; central obesity 14%; and hyperglycemia 9%. MetS was present in 11 (17%) patients. The presence of MetS was not associated with patients' gender, age, disease severity, disease duration, or CTG repeat length (P>0.05). Patients with MetS had significantly lower total SF-36 scores as a measure of quality of life in comparison to patients without MetS (P<0.05). Conclusion: Although certain components of MetS were very frequent in patients with DM1, only 17% met the criteria for MetS.

    Original languageEnglish
    JournalMuscle and Nerve
    Volume52
    Issue number2
    Pages (from-to)273-277
    Number of pages5
    ISSN0148-639X
    DOIs
    Publication statusPublished - 01.08.2015

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