Meeting report - Desmosome dysfunction and disease: Alpine desmosome disease meeting

Volker Spindler*, Brenda Gerull, Kathleen J. Green, Andrew P. Kowalczyk, Rudolf Leube, Ali J. Marian, Hendrik Milting, Eliane J. Müller, Carien Niessen, Aimee S. Payne, Nicolas Schlegel, Enno Schmidt, Pavel Strnad, Ritva Tikkanen, Franziska Vielmuth, Jens Waschke*

*Corresponding author for this work
4 Citations (Scopus)

Abstract

Desmosome diseases are caused by dysfunction of desmosomes, which anchor intermediate filaments (IFs) at sites of cell-cell adhesion. For many decades, the focus of attention has been on the role of actin filament-associated adherens junctions in development and disease, especially cancer. However, interference with the function of desmosomes, their molecular constituents or their attachments to IFs has now emerged as a major contributor to a variety of diseases affecting different tissues and organs including skin, heart and the digestive tract. The first Alpine desmosome disease meeting (ADDM) held in Grainau, Germany, in October 2022 brought together international researchers from the basic sciences with clinical experts from diverse fields to share and discuss their ideas and concepts on desmosome function and dysfunction in the different cell types involved in desmosome diseases. Besides the prototypic desmosomal diseases pemphigus and arrhythmogenic cardiomyopathy, the role of desmosome dysfunction in inflammatory bowel diseases and eosinophilic esophagitis was discussed.

Original languageEnglish
Article numberjcs260832
JournalJournal of Cell Science
Volume136
Issue number1
ISSN0021-9533
DOIs
Publication statusPublished - 01.01.2023

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)
  • Centers: Center for Research on Inflammation of the Skin (CRIS)

DFG Research Classification Scheme

  • 205-19 Dermatology

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