TY - JOUR
T1 - Meeting report - Desmosome dysfunction and disease
T2 - Alpine desmosome disease meeting
AU - Spindler, Volker
AU - Gerull, Brenda
AU - Green, Kathleen J.
AU - Kowalczyk, Andrew P.
AU - Leube, Rudolf
AU - Marian, Ali J.
AU - Milting, Hendrik
AU - Müller, Eliane J.
AU - Niessen, Carien
AU - Payne, Aimee S.
AU - Schlegel, Nicolas
AU - Schmidt, Enno
AU - Strnad, Pavel
AU - Tikkanen, Ritva
AU - Vielmuth, Franziska
AU - Waschke, Jens
N1 - Publisher Copyright:
© 2023. Published by The Company of Biologists Ltd.
PY - 2023/1/1
Y1 - 2023/1/1
N2 - Desmosome diseases are caused by dysfunction of desmosomes, which anchor intermediate filaments (IFs) at sites of cell-cell adhesion. For many decades, the focus of attention has been on the role of actin filament-associated adherens junctions in development and disease, especially cancer. However, interference with the function of desmosomes, their molecular constituents or their attachments to IFs has now emerged as a major contributor to a variety of diseases affecting different tissues and organs including skin, heart and the digestive tract. The first Alpine desmosome disease meeting (ADDM) held in Grainau, Germany, in October 2022 brought together international researchers from the basic sciences with clinical experts from diverse fields to share and discuss their ideas and concepts on desmosome function and dysfunction in the different cell types involved in desmosome diseases. Besides the prototypic desmosomal diseases pemphigus and arrhythmogenic cardiomyopathy, the role of desmosome dysfunction in inflammatory bowel diseases and eosinophilic esophagitis was discussed.
AB - Desmosome diseases are caused by dysfunction of desmosomes, which anchor intermediate filaments (IFs) at sites of cell-cell adhesion. For many decades, the focus of attention has been on the role of actin filament-associated adherens junctions in development and disease, especially cancer. However, interference with the function of desmosomes, their molecular constituents or their attachments to IFs has now emerged as a major contributor to a variety of diseases affecting different tissues and organs including skin, heart and the digestive tract. The first Alpine desmosome disease meeting (ADDM) held in Grainau, Germany, in October 2022 brought together international researchers from the basic sciences with clinical experts from diverse fields to share and discuss their ideas and concepts on desmosome function and dysfunction in the different cell types involved in desmosome diseases. Besides the prototypic desmosomal diseases pemphigus and arrhythmogenic cardiomyopathy, the role of desmosome dysfunction in inflammatory bowel diseases and eosinophilic esophagitis was discussed.
UR - http://www.scopus.com/inward/record.url?scp=85145492651&partnerID=8YFLogxK
U2 - 10.1242/jcs.260832
DO - 10.1242/jcs.260832
M3 - Journal articles
C2 - 36594662
AN - SCOPUS:85145492651
SN - 0021-9533
VL - 136
JO - Journal of Cell Science
JF - Journal of Cell Science
IS - 1
M1 - jcs260832
ER -